Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors

Three inhibitors of S‐adenosylmethionine‐mediated transmethylation, 5′‐methylthioadenosine (MTA), 2′‐deoxyadenosine and sinefungin, inhibited in vitro invasion by a highly invasive clone (Cl‐30) of rat ascites hepatoma cells, AH 130 (AH cells). Difluoromethylthioadenosine (DFMTA), a non‐metabolizabl...

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Autores principales: Sbinkai, Kiyoko, Mukai, Mutsuko, Horai, Takeshi, Ohigashi, Hiroaki, Nishikawa, Seiji, Inoue, Hideo, Takeda, Yoshiro, Akedo, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917839/
https://www.ncbi.nlm.nih.gov/pubmed/2555319
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01703.x
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author Sbinkai, Kiyoko
Mukai, Mutsuko
Horai, Takeshi
Ohigashi, Hiroaki
Nishikawa, Seiji
Inoue, Hideo
Takeda, Yoshiro
Akedo, Hitoshi
author_facet Sbinkai, Kiyoko
Mukai, Mutsuko
Horai, Takeshi
Ohigashi, Hiroaki
Nishikawa, Seiji
Inoue, Hideo
Takeda, Yoshiro
Akedo, Hitoshi
author_sort Sbinkai, Kiyoko
collection PubMed
description Three inhibitors of S‐adenosylmethionine‐mediated transmethylation, 5′‐methylthioadenosine (MTA), 2′‐deoxyadenosine and sinefungin, inhibited in vitro invasion by a highly invasive clone (Cl‐30) of rat ascites hepatoma cells, AH 130 (AH cells). Difluoromethylthioadenosine (DFMTA), a non‐metabolizable derivative of MTA, also caused strong inhibition of invasion at concentrations that did not suppress the growth of the tumor cells. Cl‐30 cells precultured in methionine‐depleted medium showed decreased invasiveness. DFMTA was also effective on the invasion by fibrosarcoma, B16 melanoma and human lung carcinoma cell lines.
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spelling pubmed-59178392018-05-11 Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors Sbinkai, Kiyoko Mukai, Mutsuko Horai, Takeshi Ohigashi, Hiroaki Nishikawa, Seiji Inoue, Hideo Takeda, Yoshiro Akedo, Hitoshi Jpn J Cancer Res Rapid Communication Three inhibitors of S‐adenosylmethionine‐mediated transmethylation, 5′‐methylthioadenosine (MTA), 2′‐deoxyadenosine and sinefungin, inhibited in vitro invasion by a highly invasive clone (Cl‐30) of rat ascites hepatoma cells, AH 130 (AH cells). Difluoromethylthioadenosine (DFMTA), a non‐metabolizable derivative of MTA, also caused strong inhibition of invasion at concentrations that did not suppress the growth of the tumor cells. Cl‐30 cells precultured in methionine‐depleted medium showed decreased invasiveness. DFMTA was also effective on the invasion by fibrosarcoma, B16 melanoma and human lung carcinoma cell lines. Blackwell Publishing Ltd 1989-08 /pmc/articles/PMC5917839/ /pubmed/2555319 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01703.x Text en
spellingShingle Rapid Communication
Sbinkai, Kiyoko
Mukai, Mutsuko
Horai, Takeshi
Ohigashi, Hiroaki
Nishikawa, Seiji
Inoue, Hideo
Takeda, Yoshiro
Akedo, Hitoshi
Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title_full Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title_fullStr Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title_full_unstemmed Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title_short Inhibition of in vitro Tumor Cell Invasion by Transmethylation Inhibitors
title_sort inhibition of in vitro tumor cell invasion by transmethylation inhibitors
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917839/
https://www.ncbi.nlm.nih.gov/pubmed/2555319
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01703.x
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