Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas

In this study we examined the expression of platelet‐derived growth factor (PDGF) A‐chain and PDGF receptor genes in seven human gastric carcinoma cell lines and 15 gastric carcinoma tissues. Expression of mRNA for PDGF A‐chain was found in all gastric cell lines and all gastric carcinoma tissues. T...

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Autores principales: Tsuda, Toshitaka, Yoshida, Kazuhiro, Tsujino, Tetsuhiro, Nakayama, Hirofumi, Kajiyama, Goro, Tahara, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917854/
https://www.ncbi.nlm.nih.gov/pubmed/2557315
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01719.x
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author Tsuda, Toshitaka
Yoshida, Kazuhiro
Tsujino, Tetsuhiro
Nakayama, Hirofumi
Kajiyama, Goro
Tahara, Eiichi
author_facet Tsuda, Toshitaka
Yoshida, Kazuhiro
Tsujino, Tetsuhiro
Nakayama, Hirofumi
Kajiyama, Goro
Tahara, Eiichi
author_sort Tsuda, Toshitaka
collection PubMed
description In this study we examined the expression of platelet‐derived growth factor (PDGF) A‐chain and PDGF receptor genes in seven human gastric carcinoma cell lines and 15 gastric carcinoma tissues. Expression of mRNA for PDGF A‐chain was found in all gastric cell lines and all gastric carcinoma tissues. Two of the seven gastric carcinoma cell lines expressed PDGF receptor mRNA. Out of the 15 gastric carcinoma tissues, eight showed enhanced expression of PDGF receptor mRNA and all of them demonstrated prominent fibrous stroma. Moreover, the incidence of enhanced expression of PDGF receptor mRNA was higher in scirrhous carcinoma than in well differentiated adenocarcinoma. These results strongly suggest that PDGF produced by tumor cells acts as a paracrine growth factor for production of fibrous stroma in gastric carcinomas
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spelling pubmed-59178542018-05-11 Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas Tsuda, Toshitaka Yoshida, Kazuhiro Tsujino, Tetsuhiro Nakayama, Hirofumi Kajiyama, Goro Tahara, Eiichi Jpn J Cancer Res Rapid Communication In this study we examined the expression of platelet‐derived growth factor (PDGF) A‐chain and PDGF receptor genes in seven human gastric carcinoma cell lines and 15 gastric carcinoma tissues. Expression of mRNA for PDGF A‐chain was found in all gastric cell lines and all gastric carcinoma tissues. Two of the seven gastric carcinoma cell lines expressed PDGF receptor mRNA. Out of the 15 gastric carcinoma tissues, eight showed enhanced expression of PDGF receptor mRNA and all of them demonstrated prominent fibrous stroma. Moreover, the incidence of enhanced expression of PDGF receptor mRNA was higher in scirrhous carcinoma than in well differentiated adenocarcinoma. These results strongly suggest that PDGF produced by tumor cells acts as a paracrine growth factor for production of fibrous stroma in gastric carcinomas Blackwell Publishing Ltd 1989-09 /pmc/articles/PMC5917854/ /pubmed/2557315 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01719.x Text en
spellingShingle Rapid Communication
Tsuda, Toshitaka
Yoshida, Kazuhiro
Tsujino, Tetsuhiro
Nakayama, Hirofumi
Kajiyama, Goro
Tahara, Eiichi
Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title_full Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title_fullStr Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title_full_unstemmed Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title_short Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
title_sort coexpression of platelet‐derived growth factor (pdgf) a‐chain and pdgf receptor genes in human gastric carcinomas
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917854/
https://www.ncbi.nlm.nih.gov/pubmed/2557315
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01719.x
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