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Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo

1,2‐Dioleoyl‐rac‐glycerol, a potent activator of protein kinase C, was found to enhance the growth‐inhibitory effect of triamcinolone acetonide on L5178Y lymphoblasts in adrenalectomized, male DBA/2 mice. On the other hand, in mice without adrenalectomy, it markedly inhibited tumor growth without in...

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Detalles Bibliográficos
Autores principales: Fukusen, Naomi, Kido, Hiroshi, Kato, Yasuhisa, Ishidoh, Kazumi, Katunuma, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917875/
https://www.ncbi.nlm.nih.gov/pubmed/2559070
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01634.x
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author Fukusen, Naomi
Kido, Hiroshi
Kato, Yasuhisa
Ishidoh, Kazumi
Katunuma, Nobuhiko
author_facet Fukusen, Naomi
Kido, Hiroshi
Kato, Yasuhisa
Ishidoh, Kazumi
Katunuma, Nobuhiko
author_sort Fukusen, Naomi
collection PubMed
description 1,2‐Dioleoyl‐rac‐glycerol, a potent activator of protein kinase C, was found to enhance the growth‐inhibitory effect of triamcinolone acetonide on L5178Y lymphoblasts in adrenalectomized, male DBA/2 mice. On the other hand, in mice without adrenalectomy, it markedly inhibited tumor growth without increasing the plasma level of corticosterone or adrenocorticotropic hormone or reducing the body weight. These results suggest that diacylglycerol enhances the action of endogenous glucocorticoid to a sufficient level to inhibit the growth of lymphoblasts. Of various diacylglycerols with different carbon chain lengths tested, 1,2‐dioleoyl‐rac‐glycerol was the most potent growth inhibitor and was maximally effective at a dose of above 30 μg/100 g body weight. This finding suggests that diacylglycerols may he useful for enhancing the antitumor effect of a low dose of glucocorticoid or endogenous glucocorticoid on lymphoblasts without any significant side effect.
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spelling pubmed-59178752018-05-11 Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo Fukusen, Naomi Kido, Hiroshi Kato, Yasuhisa Ishidoh, Kazumi Katunuma, Nobuhiko Jpn J Cancer Res Article 1,2‐Dioleoyl‐rac‐glycerol, a potent activator of protein kinase C, was found to enhance the growth‐inhibitory effect of triamcinolone acetonide on L5178Y lymphoblasts in adrenalectomized, male DBA/2 mice. On the other hand, in mice without adrenalectomy, it markedly inhibited tumor growth without increasing the plasma level of corticosterone or adrenocorticotropic hormone or reducing the body weight. These results suggest that diacylglycerol enhances the action of endogenous glucocorticoid to a sufficient level to inhibit the growth of lymphoblasts. Of various diacylglycerols with different carbon chain lengths tested, 1,2‐dioleoyl‐rac‐glycerol was the most potent growth inhibitor and was maximally effective at a dose of above 30 μg/100 g body weight. This finding suggests that diacylglycerols may he useful for enhancing the antitumor effect of a low dose of glucocorticoid or endogenous glucocorticoid on lymphoblasts without any significant side effect. Blackwell Publishing Ltd 1989-10 /pmc/articles/PMC5917875/ /pubmed/2559070 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01634.x Text en
spellingShingle Article
Fukusen, Naomi
Kido, Hiroshi
Kato, Yasuhisa
Ishidoh, Kazumi
Katunuma, Nobuhiko
Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title_full Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title_fullStr Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title_full_unstemmed Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title_short Diacylglycerols Enhance the Anti‐tumor Effect of Glucocorticoid on L5178Y Lymphoblasts in vivo
title_sort diacylglycerols enhance the anti‐tumor effect of glucocorticoid on l5178y lymphoblasts in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917875/
https://www.ncbi.nlm.nih.gov/pubmed/2559070
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01634.x
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