Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells

Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß(1) produced an activity that stimulated the growth of K562 ce...

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Detalles Bibliográficos
Autores principales: Komatsu, Keiko, Nakamura, Hiroyuki, Shinkai, Kiyoko, Akedo, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917882/
https://www.ncbi.nlm.nih.gov/pubmed/2515176
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01628.x
Descripción
Sumario:Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß(1) produced an activity that stimulated the growth of K562 cells. This activity was non‐dialyzable. acid‐stable, heat‐sensitive and partially Inactivated by pronase treatment. These results suggest a mutual growth reliance between the leukemic cells and fibroblasts mediated by paracrine growth factors produced by these cells.

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