Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells

Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß(1) produced an activity that stimulated the growth of K562 ce...

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Detalles Bibliográficos
Autores principales: Komatsu, Keiko, Nakamura, Hiroyuki, Shinkai, Kiyoko, Akedo, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917882/
https://www.ncbi.nlm.nih.gov/pubmed/2515176
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01628.x
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author Komatsu, Keiko
Nakamura, Hiroyuki
Shinkai, Kiyoko
Akedo, Hitoshi
author_facet Komatsu, Keiko
Nakamura, Hiroyuki
Shinkai, Kiyoko
Akedo, Hitoshi
author_sort Komatsu, Keiko
collection PubMed
description Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß(1) produced an activity that stimulated the growth of K562 cells. This activity was non‐dialyzable. acid‐stable, heat‐sensitive and partially Inactivated by pronase treatment. These results suggest a mutual growth reliance between the leukemic cells and fibroblasts mediated by paracrine growth factors produced by these cells.
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spelling pubmed-59178822018-05-11 Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells Komatsu, Keiko Nakamura, Hiroyuki Shinkai, Kiyoko Akedo, Hitoshi Jpn J Cancer Res Rapid Communication Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß(1) produced an activity that stimulated the growth of K562 cells. This activity was non‐dialyzable. acid‐stable, heat‐sensitive and partially Inactivated by pronase treatment. These results suggest a mutual growth reliance between the leukemic cells and fibroblasts mediated by paracrine growth factors produced by these cells. Blackwell Publishing Ltd 1989-10 /pmc/articles/PMC5917882/ /pubmed/2515176 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01628.x Text en
spellingShingle Rapid Communication
Komatsu, Keiko
Nakamura, Hiroyuki
Shinkai, Kiyoko
Akedo, Hitoshi
Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title_full Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title_fullStr Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title_full_unstemmed Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title_short Secretion of Transforming Growth Factor‐ß by Human Myelogenous Leukemic Cells and Its Possible Role in Proliferation of the Leukemic Cells
title_sort secretion of transforming growth factor‐ß by human myelogenous leukemic cells and its possible role in proliferation of the leukemic cells
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917882/
https://www.ncbi.nlm.nih.gov/pubmed/2515176
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01628.x
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