Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer

c‐erbB‐2 oncogenc has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co‐amplified c‐myc and c‐erbB‐2 oncogenes: a portion of the amplified c‐erbB‐2 oncogene was found to be rearranged. Furthermore, c‐myc an...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Terumasa, Ueyama, Yoshito, Tamaoki, Norikazu, Yamaguchi, Sachiko, Shibuya, Masabumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917887/
https://www.ncbi.nlm.nih.gov/pubmed/2575609
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01626.x
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author Tsuchiya, Terumasa
Ueyama, Yoshito
Tamaoki, Norikazu
Yamaguchi, Sachiko
Shibuya, Masabumi
author_facet Tsuchiya, Terumasa
Ueyama, Yoshito
Tamaoki, Norikazu
Yamaguchi, Sachiko
Shibuya, Masabumi
author_sort Tsuchiya, Terumasa
collection PubMed
description c‐erbB‐2 oncogenc has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co‐amplified c‐myc and c‐erbB‐2 oncogenes: a portion of the amplified c‐erbB‐2 oncogene was found to be rearranged. Furthermore, c‐myc and c‐erbB‐2 oncogenes were over‐expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tutnorigenic in nude mice. These results might suggest that activated c‐myc and c‐erbB‐2 oncogenes co‐operate and influence the malignant state of some gastric carcinomas.
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spelling pubmed-59178872018-05-11 Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer Tsuchiya, Terumasa Ueyama, Yoshito Tamaoki, Norikazu Yamaguchi, Sachiko Shibuya, Masabumi Jpn J Cancer Res Rapid Communication c‐erbB‐2 oncogenc has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co‐amplified c‐myc and c‐erbB‐2 oncogenes: a portion of the amplified c‐erbB‐2 oncogene was found to be rearranged. Furthermore, c‐myc and c‐erbB‐2 oncogenes were over‐expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tutnorigenic in nude mice. These results might suggest that activated c‐myc and c‐erbB‐2 oncogenes co‐operate and influence the malignant state of some gastric carcinomas. Blackwell Publishing Ltd 1989-10 /pmc/articles/PMC5917887/ /pubmed/2575609 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01626.x Text en
spellingShingle Rapid Communication
Tsuchiya, Terumasa
Ueyama, Yoshito
Tamaoki, Norikazu
Yamaguchi, Sachiko
Shibuya, Masabumi
Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title_full Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title_fullStr Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title_full_unstemmed Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title_short Co‐amplification of c‐myc and c‐erbB‐2 Oncogenes in a Poorly Differentiated Human Gastric Cancer
title_sort co‐amplification of c‐myc and c‐erbb‐2 oncogenes in a poorly differentiated human gastric cancer
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917887/
https://www.ncbi.nlm.nih.gov/pubmed/2575609
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01626.x
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