In vivo Antitumor Mechanism of Natural Human Tumor Necrosis Factor Involving a T Cell‐mediated Immunological Route

We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n‐TNF on Meth A sarcoma implanted in BALB/c...

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Detalles Bibliográficos
Autores principales: Asami, Tetsuya, Imai, Meroni, Tanaka, Yasuo, Hosaka, Yoshitaka, Kato, Kazuharu, Nakamura, Norio, Horisawa, Yoshifumi, Ashida, Yoshikazu, Kanamori, Toshinori, Nobuhara, Masahiro, Kurimoto, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917930/
https://www.ncbi.nlm.nih.gov/pubmed/2516844
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01648.x
Descripción
Sumario:We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n‐TNF on Meth A sarcoma implanted in BALB/c mice pretreated with monoclonal antibody against T cell‐specific surface antigen (Thy‐1) was significantly diminished. Furthermore, when BALB/c mice were treated with T cell subset‐specific monoclonal antibodies, anti‐L3T4 or anti‐Lyt‐2.2, the antitumor effect of n‐TNF on Meth A sarcoma was significantly reduced. Therefore, it was suggested that the in vivo antitumor mechanism of n‐TNF might involve a T cell‐mediated immunological route.

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