Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF(1) mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were obse...

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Detalles Bibliográficos
Autores principales: Esumi, Hiroyasu, Ohgaki, Hiroko, Kohzen, Emiko, Takayama, Shozo, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917934/
https://www.ncbi.nlm.nih.gov/pubmed/2516847
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01651.x
Descripción
Sumario:The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF(1) mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment.

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