Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF(1) mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were obse...

Descripción completa

Detalles Bibliográficos
Autores principales: Esumi, Hiroyasu, Ohgaki, Hiroko, Kohzen, Emiko, Takayama, Shozo, Sugimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917934/
https://www.ncbi.nlm.nih.gov/pubmed/2516847
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01651.x
_version_ 1783317322527670272
author Esumi, Hiroyasu
Ohgaki, Hiroko
Kohzen, Emiko
Takayama, Shozo
Sugimura, Takashi
author_facet Esumi, Hiroyasu
Ohgaki, Hiroko
Kohzen, Emiko
Takayama, Shozo
Sugimura, Takashi
author_sort Esumi, Hiroyasu
collection PubMed
description The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF(1) mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment.
format Online
Article
Text
id pubmed-5917934
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59179342018-05-11 Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Esumi, Hiroyasu Ohgaki, Hiroko Kohzen, Emiko Takayama, Shozo Sugimura, Takashi Jpn J Cancer Res Article The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF(1) mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment. Blackwell Publishing Ltd 1989-12 /pmc/articles/PMC5917934/ /pubmed/2516847 http://dx.doi.org/10.1111/j.1349-7006.1989.tb01651.x Text en
spellingShingle Article
Esumi, Hiroyasu
Ohgaki, Hiroko
Kohzen, Emiko
Takayama, Shozo
Sugimura, Takashi
Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title_full Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title_fullStr Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title_full_unstemmed Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title_short Induction of Lymphoma in CDF(1) Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
title_sort induction of lymphoma in cdf(1) mice by the food mutagen, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917934/
https://www.ncbi.nlm.nih.gov/pubmed/2516847
http://dx.doi.org/10.1111/j.1349-7006.1989.tb01651.x
work_keys_str_mv AT esumihiroyasu inductionoflymphomaincdf1micebythefoodmutagen2aminolmethyl6phenylimidazo45bpyridine
AT ohgakihiroko inductionoflymphomaincdf1micebythefoodmutagen2aminolmethyl6phenylimidazo45bpyridine
AT kohzenemiko inductionoflymphomaincdf1micebythefoodmutagen2aminolmethyl6phenylimidazo45bpyridine
AT takayamashozo inductionoflymphomaincdf1micebythefoodmutagen2aminolmethyl6phenylimidazo45bpyridine
AT sugimuratakashi inductionoflymphomaincdf1micebythefoodmutagen2aminolmethyl6phenylimidazo45bpyridine

Ejemplares similares