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Kinetics of Internalization and Cytotoxicity of Transferrin‐Neocarzinostatin Conjugate in Human Leukemia Cell Line, K562

Human serum transferrin was conjugated with an anticancer‐active polypeptide, neocarzinostatin, by using N‐succinimidy1‐3‐(2‐pyridyldithio)propionate. The conjugate consisted of 1.8 mol of neocarzinostatin per 1 mol of transferrin on average and retained cytotoxic activity against human tumor cells....

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Detalles Bibliográficos
Autores principales:	Kohgo, Yutaka, Kondo, Hitoshi, Kato, Junji, Sasaki, Katsunori, Tsushima, Nobuyasu, Nishisato, Takuji, Hirayama, Michiaki, Fujikawa, Koshi, Shintani, Naoaki, Mogi, Yoshihiro, Niitsu, Yoshiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1990
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917957/ https://www.ncbi.nlm.nih.gov/pubmed/2139019 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02512.x

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