A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐...

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Detalles Bibliográficos
Autores principales: Kato, Nobuyuki, Hijikata, Makoto, Ootsuyama, Yuko, Nakagawa, Masanori, Ohkoshi, Showgo, Shimotohno, Kunitada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917981/
https://www.ncbi.nlm.nih.gov/pubmed/2176200
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02518.x
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author Kato, Nobuyuki
Hijikata, Makoto
Ootsuyama, Yuko
Nakagawa, Masanori
Ohkoshi, Showgo
Shimotohno, Kunitada
author_facet Kato, Nobuyuki
Hijikata, Makoto
Ootsuyama, Yuko
Nakagawa, Masanori
Ohkoshi, Showgo
Shimotohno, Kunitada
author_sort Kato, Nobuyuki
collection PubMed
description A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.
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spelling pubmed-59179812018-05-11 A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection Kato, Nobuyuki Hijikata, Makoto Ootsuyama, Yuko Nakagawa, Masanori Ohkoshi, Showgo Shimotohno, Kunitada Jpn J Cancer Res Rapid Communication A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus. Blackwell Publishing Ltd 1990-11 /pmc/articles/PMC5917981/ /pubmed/2176200 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02518.x Text en
spellingShingle Rapid Communication
Kato, Nobuyuki
Hijikata, Makoto
Ootsuyama, Yuko
Nakagawa, Masanori
Ohkoshi, Showgo
Shimotohno, Kunitada
A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title_full A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title_fullStr A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title_full_unstemmed A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title_short A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection
title_sort structural protein encoded by the 5′ region of the hepatitis c virus genome efficiently detects viral infection
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917981/
https://www.ncbi.nlm.nih.gov/pubmed/2176200
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02518.x
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