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Reversal of Methotrexate Cytotoxicity to Human Bone Marrow Cells and Leukemic K562 Cells by Leucovorin: Methotrexate Polyglutamates Formation as a Possible Important Factor

Methotrexate (MIX) is metabolized intracellularly to MTX‐polyglutamates (MTX‐PGs), which markedly inhibit several folate‐dependent enzymes. Polyglutamation defect, therefore, is one of the important factors in drug resistance. In this study, reversal of MTX cytotoxicity by l‐leucovorin (l‐LV) was in...

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Detalles Bibliográficos
Autores principales:	Koizumi, Shoichi, Ueno, Yoshiki, Ohno, Ichiro, Ichihara, Tsuyoshi, Tamaru, Yoichi, Matsukawa, Harumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1990
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917995/ https://www.ncbi.nlm.nih.gov/pubmed/1702414 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02529.x

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