Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma

We investigated the expression of transforming growth factor β1 (TGF‐β1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF‐β1 mRNA at different levels, indicating the presence of activated transcription of TGF‐β1 gene in hum...

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Detalles Bibliográficos
Autores principales: Ito, Nobuyuki, Kawata, Sumio, Tamura, Shinji, Takaishi, Kenji, Yabuuchi, Iwao, Matsuda, Yasuo, Nishioka, Minoru, Tarui, Seiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918001/
https://www.ncbi.nlm.nih.gov/pubmed/1703520
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02678.x
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author Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Yabuuchi, Iwao
Matsuda, Yasuo
Nishioka, Minoru
Tarui, Seiichiro
author_facet Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Yabuuchi, Iwao
Matsuda, Yasuo
Nishioka, Minoru
Tarui, Seiichiro
author_sort Ito, Nobuyuki
collection PubMed
description We investigated the expression of transforming growth factor β1 (TGF‐β1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF‐β1 mRNA at different levels, indicating the presence of activated transcription of TGF‐β1 gene in human HCC tissues in vivo. The level of TGF‐β1 mRNA expression showed no relationship to main tumor size or plasma α‐fetoprotein level. Some HCC tissues presenting a relatively low grade of histological differentiation showed the highest levels of TGF‐β1 mRNA expression.
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spelling pubmed-59180012018-05-11 Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma Ito, Nobuyuki Kawata, Sumio Tamura, Shinji Takaishi, Kenji Yabuuchi, Iwao Matsuda, Yasuo Nishioka, Minoru Tarui, Seiichiro Jpn J Cancer Res Rapid Communication We investigated the expression of transforming growth factor β1 (TGF‐β1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF‐β1 mRNA at different levels, indicating the presence of activated transcription of TGF‐β1 gene in human HCC tissues in vivo. The level of TGF‐β1 mRNA expression showed no relationship to main tumor size or plasma α‐fetoprotein level. Some HCC tissues presenting a relatively low grade of histological differentiation showed the highest levels of TGF‐β1 mRNA expression. Blackwell Publishing Ltd 1990-12 /pmc/articles/PMC5918001/ /pubmed/1703520 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02678.x Text en
spellingShingle Rapid Communication
Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Yabuuchi, Iwao
Matsuda, Yasuo
Nishioka, Minoru
Tarui, Seiichiro
Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title_full Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title_fullStr Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title_full_unstemmed Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title_short Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
title_sort expression of transforming growth factor‐β1 mrna in human hepatocellular carcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918001/
https://www.ncbi.nlm.nih.gov/pubmed/1703520
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02678.x
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