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Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate

The chemopreventive actions of sodium selenite (SS), magnesium chloride (MC), ascorbic acid (AA) and retinyl acetate (RA), given singly or in combinations, on mammary carcinogenesis induced by 30 mg of 7,12‐dimethylbenz[a]anthracene (DMBA) in female adult rats were evaluated. Administration of modul...

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Autores principales: Nitin Rao, Araga Ramesha, Rao, Araga Ramesha, Jannu, Laxmi Narayna, Hussain, Syed Perwez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918007/
https://www.ncbi.nlm.nih.gov/pubmed/2125993
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02685.x
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author Nitin Rao, Araga Ramesha
Rao, Araga Ramesha
Jannu, Laxmi Narayna
Hussain, Syed Perwez
author_facet Nitin Rao, Araga Ramesha
Rao, Araga Ramesha
Jannu, Laxmi Narayna
Hussain, Syed Perwez
author_sort Nitin Rao, Araga Ramesha
collection PubMed
description The chemopreventive actions of sodium selenite (SS), magnesium chloride (MC), ascorbic acid (AA) and retinyl acetate (RA), given singly or in combinations, on mammary carcinogenesis induced by 30 mg of 7,12‐dimethylbenz[a]anthracene (DMBA) in female adult rats were evaluated. Administration of modulators was carried out from the age of 40±3 days to 240±3 days. When DMBA alone was given 100% of the rats developed mammary tumors. When modulators were given singly the tumor incidences were reduced to 51.77% (SS), 46.4% (MC), 57.1% (AA) and 48.1% (RA). When the modulators were given in combination of twos, the tumor incidences were further reduced to 29.5% (SS + MC), 31% (SS + AA), 29.6% (SS + RA), 25.9% (MC + AA), 31.8% (MC + RA) and 34.6% (AA + RA). Administration of modulators in combinations of threes resulted in still further reduction of tumor incidences to 22.2% (SS + MC + AA), 19.2% (SS + MC + RA), 16% (MC + AA + RA) and 23.1% (AA + RA + SS). When all four modulators were given concurrently the tumor incidence was only 12%. Further, the number of tumors per tumor‐bearing animal declined with the increase in the number of agents used in combination for modulation.
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spelling pubmed-59180072018-05-11 Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate Nitin Rao, Araga Ramesha Rao, Araga Ramesha Jannu, Laxmi Narayna Hussain, Syed Perwez Jpn J Cancer Res Article The chemopreventive actions of sodium selenite (SS), magnesium chloride (MC), ascorbic acid (AA) and retinyl acetate (RA), given singly or in combinations, on mammary carcinogenesis induced by 30 mg of 7,12‐dimethylbenz[a]anthracene (DMBA) in female adult rats were evaluated. Administration of modulators was carried out from the age of 40±3 days to 240±3 days. When DMBA alone was given 100% of the rats developed mammary tumors. When modulators were given singly the tumor incidences were reduced to 51.77% (SS), 46.4% (MC), 57.1% (AA) and 48.1% (RA). When the modulators were given in combination of twos, the tumor incidences were further reduced to 29.5% (SS + MC), 31% (SS + AA), 29.6% (SS + RA), 25.9% (MC + AA), 31.8% (MC + RA) and 34.6% (AA + RA). Administration of modulators in combinations of threes resulted in still further reduction of tumor incidences to 22.2% (SS + MC + AA), 19.2% (SS + MC + RA), 16% (MC + AA + RA) and 23.1% (AA + RA + SS). When all four modulators were given concurrently the tumor incidence was only 12%. Further, the number of tumors per tumor‐bearing animal declined with the increase in the number of agents used in combination for modulation. Blackwell Publishing Ltd 1990-12 /pmc/articles/PMC5918007/ /pubmed/2125993 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02685.x Text en
spellingShingle Article
Nitin Rao, Araga Ramesha
Rao, Araga Ramesha
Jannu, Laxmi Narayna
Hussain, Syed Perwez
Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title_full Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title_fullStr Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title_full_unstemmed Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title_short Chemoprevention of 7,12‐Dimethylbenz[a]anthracene‐induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate
title_sort chemoprevention of 7,12‐dimethylbenz[a]anthracene‐induced mammary carcinogenesis in rat by the combined actions of selenium, magnesium, ascorbic acid and retinyl acetate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918007/
https://www.ncbi.nlm.nih.gov/pubmed/2125993
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02685.x
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