The Role of Bone Fracture at the Site of Carcinogen Exposure on Nickel Carcinogenesis in the Soft Tissue

The influence upon nickel subsulfide (α‐Ni(3)S(2); Ni‐SS)‐induced carcinogenesis in the soft tissue of bone fracture at the site of Ni‐SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction...

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Detalles Bibliográficos
Autores principales: Ohmori, Takaaki, Uraga, Naomi, Komi, Kiyoshi, Tabei, Ryo, Shibata, Taiho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918016/
https://www.ncbi.nlm.nih.gov/pubmed/2125994
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02686.x
Descripción
Sumario:The influence upon nickel subsulfide (α‐Ni(3)S(2); Ni‐SS)‐induced carcinogenesis in the soft tissue of bone fracture at the site of Ni‐SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.

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