X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor

The × protein of hepatitis B virus (HBV) has been shown to be a trans‐activator for viral and cellular genes. Amino acid sequences in × protein were found to be highly homologous to functionally essential sequences in the “Kunitz domain,’characteristic of Kunitz‐type serine protease inhibitors. Muta...

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Detalles Bibliográficos
Autores principales: Takada, Shinako, Koike, Katsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918017/
https://www.ncbi.nlm.nih.gov/pubmed/2125986
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02675.x
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author Takada, Shinako
Koike, Katsuro
author_facet Takada, Shinako
Koike, Katsuro
author_sort Takada, Shinako
collection PubMed
description The × protein of hepatitis B virus (HBV) has been shown to be a trans‐activator for viral and cellular genes. Amino acid sequences in × protein were found to be highly homologous to functionally essential sequences in the “Kunitz domain,’characteristic of Kunitz‐type serine protease inhibitors. Mutations at these sequences completely abolished trans‐activation. Consequently, HBV × protein resembles a serine protease inhibitor or its analogue, and may bring about trans‐activation by activating certain transcriptional factors through proteolytic cleavage alteration.
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spelling pubmed-59180172018-05-11 X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor Takada, Shinako Koike, Katsuro Jpn J Cancer Res Rapid Communication The × protein of hepatitis B virus (HBV) has been shown to be a trans‐activator for viral and cellular genes. Amino acid sequences in × protein were found to be highly homologous to functionally essential sequences in the “Kunitz domain,’characteristic of Kunitz‐type serine protease inhibitors. Mutations at these sequences completely abolished trans‐activation. Consequently, HBV × protein resembles a serine protease inhibitor or its analogue, and may bring about trans‐activation by activating certain transcriptional factors through proteolytic cleavage alteration. Blackwell Publishing Ltd 1990-12 /pmc/articles/PMC5918017/ /pubmed/2125986 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02675.x Text en
spellingShingle Rapid Communication
Takada, Shinako
Koike, Katsuro
X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title_full X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title_fullStr X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title_full_unstemmed X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title_short X Protein of Hepatitis B Virus Resembles a Serine Protease Inhibitor
title_sort x protein of hepatitis b virus resembles a serine protease inhibitor
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918017/
https://www.ncbi.nlm.nih.gov/pubmed/2125986
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02675.x
work_keys_str_mv AT takadashinako xproteinofhepatitisbvirusresemblesaserineproteaseinhibitor
AT koikekatsuro xproteinofhepatitisbvirusresemblesaserineproteaseinhibitor

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