Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate

8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant incr...

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Detalles Bibliográficos
Autores principales: Takagi, Atsuya, Sai, Kimie, Umemura, Takashi, Hasegawa, Ryuichi, Kurokawa, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918022/
https://www.ncbi.nlm.nih.gov/pubmed/2112523
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02551.x
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author Takagi, Atsuya
Sai, Kimie
Umemura, Takashi
Hasegawa, Ryuichi
Kurokawa, Yuji
author_facet Takagi, Atsuya
Sai, Kimie
Umemura, Takashi
Hasegawa, Ryuichi
Kurokawa, Yuji
author_sort Takagi, Atsuya
collection PubMed
description 8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8‐OH‐dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.
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spelling pubmed-59180222018-05-11 Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate Takagi, Atsuya Sai, Kimie Umemura, Takashi Hasegawa, Ryuichi Kurokawa, Yuji Jpn J Cancer Res Rapid Communication 8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8‐OH‐dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators. Blackwell Publishing Ltd 1990-03 /pmc/articles/PMC5918022/ /pubmed/2112523 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02551.x Text en
spellingShingle Rapid Communication
Takagi, Atsuya
Sai, Kimie
Umemura, Takashi
Hasegawa, Ryuichi
Kurokawa, Yuji
Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title_full Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title_fullStr Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title_full_unstemmed Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title_short Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate
title_sort significant increase of 8‐hydroxydeoxyguanosine in liver dna of rats following short‐term exposure to the peroxisome proliferators di(2‐ethylhexyl)phthalate and di(2‐ethylhexyl)adipate
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918022/
https://www.ncbi.nlm.nih.gov/pubmed/2112523
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02551.x
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