Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines

The effects of transforming growth factor β1 (TGF‐β1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum‐free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF‐β1 (0.5 to 4.0 ng/ml), but remained unchanged...

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Detalles Bibliográficos
Autores principales: Ito, Nobuyuki, Kawata, Sumio, Tamura, Shinji, Takaishi, Kenji, Saitoh, Ryuzo, Tarui, Seiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918033/
https://www.ncbi.nlm.nih.gov/pubmed/2161812
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02552.x
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author Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Saitoh, Ryuzo
Tarui, Seiichiro
author_facet Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Saitoh, Ryuzo
Tarui, Seiichiro
author_sort Ito, Nobuyuki
collection PubMed
description The effects of transforming growth factor β1 (TGF‐β1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum‐free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF‐β1 (0.5 to 4.0 ng/ml), but remained unchanged in the Mahlavu cells. Also the expression of c‐myc mRNA was suppressed by the addition of TGF‐β1 in the PLC/PRF/5 cells but not in the Mahlavu cells. These results indicate that TGF‐β1 might regulate cell growth, in part, by modulating c‐myc expression, although there is no direct proof that c‐myc expression is really relevant to DNA synthesis mediated by TGF‐β1.
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spelling pubmed-59180332018-05-11 Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines Ito, Nobuyuki Kawata, Sumio Tamura, Shinji Takaishi, Kenji Saitoh, Ryuzo Tarui, Seiichiro Jpn J Cancer Res Rapid Communication The effects of transforming growth factor β1 (TGF‐β1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum‐free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF‐β1 (0.5 to 4.0 ng/ml), but remained unchanged in the Mahlavu cells. Also the expression of c‐myc mRNA was suppressed by the addition of TGF‐β1 in the PLC/PRF/5 cells but not in the Mahlavu cells. These results indicate that TGF‐β1 might regulate cell growth, in part, by modulating c‐myc expression, although there is no direct proof that c‐myc expression is really relevant to DNA synthesis mediated by TGF‐β1. Blackwell Publishing Ltd 1990-03 /pmc/articles/PMC5918033/ /pubmed/2161812 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02552.x Text en
spellingShingle Rapid Communication
Ito, Nobuyuki
Kawata, Sumio
Tamura, Shinji
Takaishi, Kenji
Saitoh, Ryuzo
Tarui, Seiichiro
Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title_full Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title_fullStr Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title_full_unstemmed Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title_short Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
title_sort modulation of c‐myc expression by transforming growth factor β1 in human hepatoma cell lines
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918033/
https://www.ncbi.nlm.nih.gov/pubmed/2161812
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02552.x
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