Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter

The T‐lymphocyte‐specific tyrosine kinase gene, Ick, is expressed in T‐lymphocyte cell lines, except for several human T‐cell leukemia virus type I(HTLV‐I)‐transformed T‐lymphocyte cell lines, which produce HTLV‐I. By introducing an Ick‐expression vector, we found that Ick product suppresses gene ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohta, Masataka, Morita, Toshirou, Shimotohno, Kunitada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918062/
https://www.ncbi.nlm.nih.gov/pubmed/2116390
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02588.x
_version_ 1783317351281721344
author Ohta, Masataka
Morita, Toshirou
Shimotohno, Kunitada
author_facet Ohta, Masataka
Morita, Toshirou
Shimotohno, Kunitada
author_sort Ohta, Masataka
collection PubMed
description The T‐lymphocyte‐specific tyrosine kinase gene, Ick, is expressed in T‐lymphocyte cell lines, except for several human T‐cell leukemia virus type I(HTLV‐I)‐transformed T‐lymphocyte cell lines, which produce HTLV‐I. By introducing an Ick‐expression vector, we found that Ick product suppresses gene expression from HTLV‐I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by Ic.
format Online
Article
Text
id pubmed-5918062
institution National Center for Biotechnology Information
language English
publishDate 1990
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59180622018-05-11 Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter Ohta, Masataka Morita, Toshirou Shimotohno, Kunitada Jpn J Cancer Res Rapid Communication The T‐lymphocyte‐specific tyrosine kinase gene, Ick, is expressed in T‐lymphocyte cell lines, except for several human T‐cell leukemia virus type I(HTLV‐I)‐transformed T‐lymphocyte cell lines, which produce HTLV‐I. By introducing an Ick‐expression vector, we found that Ick product suppresses gene expression from HTLV‐I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by Ic. Blackwell Publishing Ltd 1990-05 /pmc/articles/PMC5918062/ /pubmed/2116390 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02588.x Text en
spellingShingle Rapid Communication
Ohta, Masataka
Morita, Toshirou
Shimotohno, Kunitada
Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title_full Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title_fullStr Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title_full_unstemmed Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title_short Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter
title_sort ick suppresses gene expression from various promoters including human t‐cell leukemia virus type i promoter
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918062/
https://www.ncbi.nlm.nih.gov/pubmed/2116390
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02588.x
work_keys_str_mv AT ohtamasataka icksuppressesgeneexpressionfromvariouspromotersincludinghumantcellleukemiavirustypeipromoter
AT moritatoshirou icksuppressesgeneexpressionfromvariouspromotersincludinghumantcellleukemiavirustypeipromoter
AT shimotohnokunitada icksuppressesgeneexpressionfromvariouspromotersincludinghumantcellleukemiavirustypeipromoter

Ejemplares similares