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Urothelial Damage and Tumor Initiation by Urinary Metabolites of Sodium o‐Phenylphenate in the Urinary Bladder of Female Rats

Intravesical instillation of 2‐phenyl‐1,4‐benzoquinone (PBQ), a metabolite of sodium o‐phenylphenate (Na‐OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resu...

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Detalles Bibliográficos
Autores principales:	Hasegawa, Ryohei, Furukawa, Fumio, Toyoda, Kazuhiro, Sato, Hidetaka, Takahashi, Michihito, Hayashi, Yuzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1990
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918068/ https://www.ncbi.nlm.nih.gov/pubmed/2116397 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02595.x

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