Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus

The three‐day‐old larvae of self‐fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01–0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA‐treated fish...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Eun‐Ho, Chang, Hwa‐Hyoung, Cha, Young‐Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918089/
https://www.ncbi.nlm.nih.gov/pubmed/2118888
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02638.x
_version_ 1783317357660209152
author Park, Eun‐Ho
Chang, Hwa‐Hyoung
Cha, Young‐Nam
author_facet Park, Eun‐Ho
Chang, Hwa‐Hyoung
Cha, Young‐Nam
author_sort Park, Eun‐Ho
collection PubMed
description The three‐day‐old larvae of self‐fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01–0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA‐treated fish. The BHA‐induced tumor incidences were clearly dose‐dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose.
format Online
Article
Text
id pubmed-5918089
institution National Center for Biotechnology Information
language English
publishDate 1990
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59180892018-05-11 Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus Park, Eun‐Ho Chang, Hwa‐Hyoung Cha, Young‐Nam Jpn J Cancer Res Article The three‐day‐old larvae of self‐fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01–0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA‐treated fish. The BHA‐induced tumor incidences were clearly dose‐dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose. Blackwell Publishing Ltd 1990-08 /pmc/articles/PMC5918089/ /pubmed/2118888 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02638.x Text en
spellingShingle Article
Park, Eun‐Ho
Chang, Hwa‐Hyoung
Cha, Young‐Nam
Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title_full Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title_fullStr Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title_full_unstemmed Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title_short Induction of Hepatic Tumors with Butylated Hydroxyanisole in the Self‐fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
title_sort induction of hepatic tumors with butylated hydroxyanisole in the self‐fertilizing hermaphroditic fish rivulus ocellatus marmoratus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918089/
https://www.ncbi.nlm.nih.gov/pubmed/2118888
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02638.x
work_keys_str_mv AT parkeunho inductionofhepatictumorswithbutylatedhydroxyanisoleintheselffertilizinghermaphroditicfishrivulusocellatusmarmoratus
AT changhwahyoung inductionofhepatictumorswithbutylatedhydroxyanisoleintheselffertilizinghermaphroditicfishrivulusocellatusmarmoratus
AT chayoungnam inductionofhepatictumorswithbutylatedhydroxyanisoleintheselffertilizinghermaphroditicfishrivulusocellatusmarmoratus

Ejemplares similares