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c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas

Ductectatic‐type mutinous cystic neoplasms of the pancreas constitute a recently recognized new human pancreatic tumor entity. Examination for the presence of point mutations at codon 12 of K‐ras by oligonucleotide hybridization in 5 adenomas and 3 carcinomas revealed alteration in 3 and 2, respecti...

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Detalles Bibliográficos
Autores principales: Yanagisawa, Akio, Kato, Yo, Ohtake, Keiko, Kitagawa, Tomoyuki, Ohashi, Kazuhiko, Hori, Masaharu, Takagi, Kunio, Haruo, Haruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918253/
https://www.ncbi.nlm.nih.gov/pubmed/1955373
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01756.x
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author Yanagisawa, Akio
Kato, Yo
Ohtake, Keiko
Kitagawa, Tomoyuki
Ohashi, Kazuhiko
Hori, Masaharu
Takagi, Kunio
Haruo, Haruo
author_facet Yanagisawa, Akio
Kato, Yo
Ohtake, Keiko
Kitagawa, Tomoyuki
Ohashi, Kazuhiko
Hori, Masaharu
Takagi, Kunio
Haruo, Haruo
author_sort Yanagisawa, Akio
collection PubMed
description Ductectatic‐type mutinous cystic neoplasms of the pancreas constitute a recently recognized new human pancreatic tumor entity. Examination for the presence of point mutations at codon 12 of K‐ras by oligonucleotide hybridization in 5 adenomas and 3 carcinomas revealed alteration in 3 and 2, respectively. In 4 of these positive cases, the transition was GGT–GAT (Gly–Asp) with the remaining one, found in a cancer, being GGT–GTT (Gly–Val). In two carcinoma cases, the same point mutation was detected both in the carcinoma area and in a coexisting adenoma component. Thus K‐ras point mutation appears to be associated with this particular type of neoplasm in the same manner as observed for typical exocrine pancreas carcinomas. Our study also indicates the possible existence of an adenoma‐carcinoma sequence in the evolution of this type of neoplasm and we suggest that K‐ras activation may be an important event in the phase of adenoma development.
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spelling pubmed-59182532018-05-11 c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas Yanagisawa, Akio Kato, Yo Ohtake, Keiko Kitagawa, Tomoyuki Ohashi, Kazuhiko Hori, Masaharu Takagi, Kunio Haruo, Haruo Jpn J Cancer Res Article Ductectatic‐type mutinous cystic neoplasms of the pancreas constitute a recently recognized new human pancreatic tumor entity. Examination for the presence of point mutations at codon 12 of K‐ras by oligonucleotide hybridization in 5 adenomas and 3 carcinomas revealed alteration in 3 and 2, respectively. In 4 of these positive cases, the transition was GGT–GAT (Gly–Asp) with the remaining one, found in a cancer, being GGT–GTT (Gly–Val). In two carcinoma cases, the same point mutation was detected both in the carcinoma area and in a coexisting adenoma component. Thus K‐ras point mutation appears to be associated with this particular type of neoplasm in the same manner as observed for typical exocrine pancreas carcinomas. Our study also indicates the possible existence of an adenoma‐carcinoma sequence in the evolution of this type of neoplasm and we suggest that K‐ras activation may be an important event in the phase of adenoma development. Blackwell Publishing Ltd 1991-10 /pmc/articles/PMC5918253/ /pubmed/1955373 http://dx.doi.org/10.1111/j.1349-7006.1991.tb01756.x Text en
spellingShingle Article
Yanagisawa, Akio
Kato, Yo
Ohtake, Keiko
Kitagawa, Tomoyuki
Ohashi, Kazuhiko
Hori, Masaharu
Takagi, Kunio
Haruo, Haruo
c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title_full c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title_fullStr c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title_full_unstemmed c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title_short c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas
title_sort c‐ki‐raspoint mutations in ductectatic‐type mucinous cystic neoplasms of the pancreas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918253/
https://www.ncbi.nlm.nih.gov/pubmed/1955373
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01756.x
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