Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)

The stomach region of hypocatalasemic mice of both sexes was X‐irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was stat...

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Detalles Bibliográficos
Autores principales: Watanabe, Hiromitsu, Ogundigie, Peter Osa, Takahashi, Tadateru, Ishimoto, Tatsuro, Ito, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1991
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918321/
https://www.ncbi.nlm.nih.gov/pubmed/1661279
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01774.x
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author Watanabe, Hiromitsu
Ogundigie, Peter Osa
Takahashi, Tadateru
Ishimoto, Tatsuro
Ito, Akihiro
author_facet Watanabe, Hiromitsu
Ogundigie, Peter Osa
Takahashi, Tadateru
Ishimoto, Tatsuro
Ito, Akihiro
author_sort Watanabe, Hiromitsu
collection PubMed
description The stomach region of hypocatalasemic mice of both sexes was X‐irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P < 0.01 in males and P < 0.05 in females) compared to a total absence of similar tumors in the non‐irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.
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spelling pubmed-59183212018-05-11 Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8) Watanabe, Hiromitsu Ogundigie, Peter Osa Takahashi, Tadateru Ishimoto, Tatsuro Ito, Akihiro Jpn J Cancer Res Article The stomach region of hypocatalasemic mice of both sexes was X‐irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P < 0.01 in males and P < 0.05 in females) compared to a total absence of similar tumors in the non‐irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs. Blackwell Publishing Ltd 1991-11 /pmc/articles/PMC5918321/ /pubmed/1661279 http://dx.doi.org/10.1111/j.1349-7006.1991.tb01774.x Text en
spellingShingle Article
Watanabe, Hiromitsu
Ogundigie, Peter Osa
Takahashi, Tadateru
Ishimoto, Tatsuro
Ito, Akihiro
Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title_full Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title_fullStr Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title_full_unstemmed Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title_short Induction of Signet Ring Cell Carcinomas in X‐Irradiated Hypocatalasemic Mice (C3H/Ob8)
title_sort induction of signet ring cell carcinomas in x‐irradiated hypocatalasemic mice (c3h/ob8)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918321/
https://www.ncbi.nlm.nih.gov/pubmed/1661279
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01774.x
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