Chromosomal Insertion and Amplification of Human Papillomavirus 16 DNA Sequences in a Cell Line of Argyrophil Small Cell Carcinoma of the Uterine Cervix

The chromosomal location of human papillomavirus (HPV) 16 DNA sequences integrated in a cell line derived from argyrophil small cell carcinoma of the uterine cervix was determined by means of fluorescence in situ hybridization (FISH). The HPV 16 DNA sequences were integrated near a fragile site and...

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Detalles Bibliográficos
Autores principales: Hori, Tada‐aki, Ichimura, Hiroshi, Minamihisamatsu, Masako, Takahashi, Ei‐ichi, Yamauchi, Masatake, Hama, Yuko, Kurimura, Osamu, Yamasaki, Masato, Kurimura, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1991
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918448/
https://www.ncbi.nlm.nih.gov/pubmed/1646197
http://dx.doi.org/10.1111/j.1349-7006.1991.tb01857.x
Descripción
Sumario:The chromosomal location of human papillomavirus (HPV) 16 DNA sequences integrated in a cell line derived from argyrophil small cell carcinoma of the uterine cervix was determined by means of fluorescence in situ hybridization (FISH). The HPV 16 DNA sequences were integrated near a fragile site and the location of the c‐myc oncogene at 8q24.1. Amplification of the integrated viral sequences resulted in an abnormally banded region. The amplified HPV 16 DNA sequences were also detected in every interphase nucleus by FISH.

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