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Okadaic Acid Is a Potent Angiogenesis Inducer

Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5...

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Detalles Bibliográficos
Autores principales: Oikawa, Tsutomu, Suganuma, Masami, Ashino‐Fuse, Hiromi, Shimamura, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918649/
https://www.ncbi.nlm.nih.gov/pubmed/1371991
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02343.x
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author Oikawa, Tsutomu
Suganuma, Masami
Ashino‐Fuse, Hiromi
Shimamura, Mariko
author_facet Oikawa, Tsutomu
Suganuma, Masami
Ashino‐Fuse, Hiromi
Shimamura, Mariko
author_sort Oikawa, Tsutomu
collection PubMed
description Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was 90 fmol/egg. These results indicated that okadaic acid exhibits angiogenic activity one order of magnitude stronger than that of TPA (reported previously). Moreover, the time‐course of angiogenesis induction by okadaic acid was much slower than that by TPA. The difference is consistent with the time‐courses of other biochemical and biological activities and also various gene expressions induced by okadaic acid and TPA, indicating that the difference in the time‐course is associated with their mechanisms of action. We conclude that okadaic acid induces angiogenesis through a different pathway than does TPA, indicating the existence of a new mechanism of angiogenesis induction.
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spelling pubmed-59186492018-05-11 Okadaic Acid Is a Potent Angiogenesis Inducer Oikawa, Tsutomu Suganuma, Masami Ashino‐Fuse, Hiromi Shimamura, Mariko Jpn J Cancer Res Rapid Communication Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was 90 fmol/egg. These results indicated that okadaic acid exhibits angiogenic activity one order of magnitude stronger than that of TPA (reported previously). Moreover, the time‐course of angiogenesis induction by okadaic acid was much slower than that by TPA. The difference is consistent with the time‐courses of other biochemical and biological activities and also various gene expressions induced by okadaic acid and TPA, indicating that the difference in the time‐course is associated with their mechanisms of action. We conclude that okadaic acid induces angiogenesis through a different pathway than does TPA, indicating the existence of a new mechanism of angiogenesis induction. Blackwell Publishing Ltd 1992-01 /pmc/articles/PMC5918649/ /pubmed/1371991 http://dx.doi.org/10.1111/j.1349-7006.1992.tb02343.x Text en
spellingShingle Rapid Communication
Oikawa, Tsutomu
Suganuma, Masami
Ashino‐Fuse, Hiromi
Shimamura, Mariko
Okadaic Acid Is a Potent Angiogenesis Inducer
title Okadaic Acid Is a Potent Angiogenesis Inducer
title_full Okadaic Acid Is a Potent Angiogenesis Inducer
title_fullStr Okadaic Acid Is a Potent Angiogenesis Inducer
title_full_unstemmed Okadaic Acid Is a Potent Angiogenesis Inducer
title_short Okadaic Acid Is a Potent Angiogenesis Inducer
title_sort okadaic acid is a potent angiogenesis inducer
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918649/
https://www.ncbi.nlm.nih.gov/pubmed/1371991
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02343.x
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