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Induced Synthesis of O(6)‐Methylguanine‐DNA Methyltransferase in Rat Hepatoma Cells Exposed to DNA‐damaging Agents

When the rat hepatoma cell line H4IIE was treated with DNA‐damaging agents such as N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG), ultraviolet light and γ‐rays, the O(6)‐methylguanine‐DNA methyltransferase activity increased 2 to 3 times over the level seen in non‐treated cells. SDS/polyacrylamide gel...

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Detalles Bibliográficos
Autores principales:	Fukuhara, Masao, Hayakawa, Hiroshi, Sakumi, Kunihiko, Sekiguchi, Mutsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1992
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918658/ https://www.ncbi.nlm.nih.gov/pubmed/1544875 http://dx.doi.org/10.1111/j.1349-7006.1992.tb02354.x

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