Phenotypic Properties of Liver Tumors Induced by Dehydroepiandrosterone in F‐344 Rats

Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>9...

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Detalles Bibliográficos
Autores principales: Rao, M. Sambasiva, Subbarao, V., Kumar, Sujata, Yeldandi, Anjana V., Reddy, Janardan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918701/
https://www.ncbi.nlm.nih.gov/pubmed/1336491
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02742.x
Descripción
Sumario:Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat The present study deals with the phenotypic properties of DHEA‐induced liver lesions. A majority of the altered areas (80–87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80–100%) lacked the marker enzymes 7‐glutamyltranspeptidase and placental form of glutathione S‐transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose‐6‐phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.

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