Telomere Elongation Frequently Observed during Tumor Metastasis

Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed‐field gel electrophoresis and gel‐hybridization using (TTAGGG)(4) as a probe. Very long size variants of telomeres were frequentl...

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Detalles Bibliográficos
Autores principales: Takada, Toshinori, Hayashi, Tatsuhiko, Arakawa, Masaaki, Kominami, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918703/
https://www.ncbi.nlm.nih.gov/pubmed/1483926
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02733.x
Descripción
Sumario:Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed‐field gel electrophoresis and gel‐hybridization using (TTAGGG)(4) as a probe. Very long size variants of telomeres were frequently observed in metastatic nodules. This suggests that at least some of the tumor cells have an ability to elongate telomeres. This elongation may compensate for the continuous loss of telomere repeats due to cell divisions, which would eventually lead to cell death.

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