Telomere Elongation Frequently Observed during Tumor Metastasis

Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed‐field gel electrophoresis and gel‐hybridization using (TTAGGG)(4) as a probe. Very long size variants of telomeres were frequentl...

Descripción completa

Detalles Bibliográficos
Autores principales: Takada, Toshinori, Hayashi, Tatsuhiko, Arakawa, Masaaki, Kominami, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918703/
https://www.ncbi.nlm.nih.gov/pubmed/1483926
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02733.x
_version_ 1783317472035733504
author Takada, Toshinori
Hayashi, Tatsuhiko
Arakawa, Masaaki
Kominami, Ryo
author_facet Takada, Toshinori
Hayashi, Tatsuhiko
Arakawa, Masaaki
Kominami, Ryo
author_sort Takada, Toshinori
collection PubMed
description Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed‐field gel electrophoresis and gel‐hybridization using (TTAGGG)(4) as a probe. Very long size variants of telomeres were frequently observed in metastatic nodules. This suggests that at least some of the tumor cells have an ability to elongate telomeres. This elongation may compensate for the continuous loss of telomere repeats due to cell divisions, which would eventually lead to cell death.
format Online
Article
Text
id pubmed-5918703
institution National Center for Biotechnology Information
language English
publishDate 1992
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59187032018-05-11 Telomere Elongation Frequently Observed during Tumor Metastasis Takada, Toshinori Hayashi, Tatsuhiko Arakawa, Masaaki Kominami, Ryo Jpn J Cancer Res Rapid Communication Changes in the number of telomere repeat arrays have been examined during metastasis of two mouse tumor cell lines. Telomeres were detected as bands and a smear by pulsed‐field gel electrophoresis and gel‐hybridization using (TTAGGG)(4) as a probe. Very long size variants of telomeres were frequently observed in metastatic nodules. This suggests that at least some of the tumor cells have an ability to elongate telomeres. This elongation may compensate for the continuous loss of telomere repeats due to cell divisions, which would eventually lead to cell death. Blackwell Publishing Ltd 1992-11 /pmc/articles/PMC5918703/ /pubmed/1483926 http://dx.doi.org/10.1111/j.1349-7006.1992.tb02733.x Text en
spellingShingle Rapid Communication
Takada, Toshinori
Hayashi, Tatsuhiko
Arakawa, Masaaki
Kominami, Ryo
Telomere Elongation Frequently Observed during Tumor Metastasis
title Telomere Elongation Frequently Observed during Tumor Metastasis
title_full Telomere Elongation Frequently Observed during Tumor Metastasis
title_fullStr Telomere Elongation Frequently Observed during Tumor Metastasis
title_full_unstemmed Telomere Elongation Frequently Observed during Tumor Metastasis
title_short Telomere Elongation Frequently Observed during Tumor Metastasis
title_sort telomere elongation frequently observed during tumor metastasis
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918703/
https://www.ncbi.nlm.nih.gov/pubmed/1483926
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02733.x
work_keys_str_mv AT takadatoshinori telomereelongationfrequentlyobservedduringtumormetastasis
AT hayashitatsuhiko telomereelongationfrequentlyobservedduringtumormetastasis
AT arakawamasaaki telomereelongationfrequentlyobservedduringtumormetastasis
AT kominamiryo telomereelongationfrequentlyobservedduringtumormetastasis

Ejemplares similares