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VLA‐4 Molecules on Tumor Cells Initiate an Adhesive Interaction with VCAM‐1 Molecules on Endothelial Cell Surface

To elucidate the role of VLA‐4 (α4β1 integrin) in tumor metastasis, we have transfected cDNA coding z4 subunit into human flbrosarcoma (HT1080) cells. VLA‐4‐overexpressing HT‐VC1 cells exhibited increased ability to interact with known ligands for VLA‐4, such as CS1 peptide and VCAM‐1 (vascular cell...

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Detalles Bibliográficos
Autores principales:	Kawaguchi, Satoshi, Kikuchi, Kokichi, Ishii, Seiichi, Takada, Yoshikazu, Kobayashi, Seiichi, Uede, Toshimitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1992
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918735/ https://www.ncbi.nlm.nih.gov/pubmed/1282907 http://dx.doi.org/10.1111/j.1349-7006.1992.tb02763.x

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