Vertical Transmission of HTLV‐1 in HTLV‐1 Carrier Rat

A female F344 rat was injected with 2.4 × 10(6) MT‐2 cells intravenously at 3 and 4 weeks old, and was mated with a non‐infected male rat at the 17th week after injection, when the dam rat contained HTLV‐1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction....

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Detalles Bibliográficos
Autores principales: Ami, Yoshihiro, Kushida, Shigeki, Matsumura, Masayuki, Yoshida, Yuki, Kameyama, Tsuneo, Sugiyama, Yoshihiro, Yagami, Ken‐ichi, Uchida, Masako, Uchida, Kazuhiko, Koiso, Kenkichi, Miwa, Masanao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918746/
https://www.ncbi.nlm.nih.gov/pubmed/1483938
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02751.x
Descripción
Sumario:A female F344 rat was injected with 2.4 × 10(6) MT‐2 cells intravenously at 3 and 4 weeks old, and was mated with a non‐infected male rat at the 17th week after injection, when the dam rat contained HTLV‐1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV‐1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once‐transmitted HTLV‐1.

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