Cargando…

Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis

BACKGROUND: Transmission dynamics of mosquito-borne viruses such as dengue, Zika and chikungunya are affected by the longevity of the adult female mosquito. Environmental conditions influence the survival of adult female Aedes mosquitoes, the primary vectors of these viruses. While the association o...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, Chris A., Comeau, Genevieve, Monaghan, Andrew J., Williamson, Daniel J., Ernst, Kacey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918765/
https://www.ncbi.nlm.nih.gov/pubmed/29695282
http://dx.doi.org/10.1186/s13071-018-2808-6
_version_ 1783317485719650304
author Schmidt, Chris A.
Comeau, Genevieve
Monaghan, Andrew J.
Williamson, Daniel J.
Ernst, Kacey C.
author_facet Schmidt, Chris A.
Comeau, Genevieve
Monaghan, Andrew J.
Williamson, Daniel J.
Ernst, Kacey C.
author_sort Schmidt, Chris A.
collection PubMed
description BACKGROUND: Transmission dynamics of mosquito-borne viruses such as dengue, Zika and chikungunya are affected by the longevity of the adult female mosquito. Environmental conditions influence the survival of adult female Aedes mosquitoes, the primary vectors of these viruses. While the association of temperature with Aedes mortality has been relatively well-explored, the role of humidity is less established. The current study’s goals were to compile knowledge of the influence of humidity on adult survival in the important vector species Aedes aegypti and Ae. albopictus, and to quantify this relationship while accounting for the modifying effect of temperature. METHODS: We performed a systematic literature review to identify studies reporting experimental results informing the relationships among temperature, humidity and adult survival in Ae. aegypti and Ae. albopictus. Using a novel simulation approach to harmonize disparate survival data, we conducted pooled survival analyses via stratified and mixed effects Cox regression to estimate temperature-dependent associations between humidity and mortality risk for these species across a broad range of temperatures and vapor pressure deficits. RESULTS: After screening 1517 articles, 17 studies (one in semi-field and 16 in laboratory settings) met inclusion criteria and collectively reported results for 192 survival experiments. We review and synthesize relevant findings from these studies. Our stratified model estimated a strong temperature-dependent association of humidity with mortality in both species, though associations were not significant for Ae. albopictus in the mixed effects model. Lowest mortality risks were estimated around 27.5 °C and 21.5 °C for Ae. aegypti and Ae. albopictus, respectively, and mortality increased non-linearly with decreasing humidity. Aedes aegypti had a survival advantage relative to Ae. albopictus in the stratified model under most conditions, but species differences were not significant in the mixed effects model. CONCLUSIONS: Humidity is associated with mortality risk in adult female Ae. aegypti in controlled settings. Data are limited at low humidities, temperature extremes, and for Ae. albopictus, and further studies should be conducted to reduce model uncertainty in these contexts. Desiccation is likely an important factor in Aedes population dynamics and viral transmission in arid regions. Models of Aedes-borne virus transmission may be improved by more comprehensively representing humidity effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2808-6) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5918765
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-59187652018-04-30 Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis Schmidt, Chris A. Comeau, Genevieve Monaghan, Andrew J. Williamson, Daniel J. Ernst, Kacey C. Parasit Vectors Research BACKGROUND: Transmission dynamics of mosquito-borne viruses such as dengue, Zika and chikungunya are affected by the longevity of the adult female mosquito. Environmental conditions influence the survival of adult female Aedes mosquitoes, the primary vectors of these viruses. While the association of temperature with Aedes mortality has been relatively well-explored, the role of humidity is less established. The current study’s goals were to compile knowledge of the influence of humidity on adult survival in the important vector species Aedes aegypti and Ae. albopictus, and to quantify this relationship while accounting for the modifying effect of temperature. METHODS: We performed a systematic literature review to identify studies reporting experimental results informing the relationships among temperature, humidity and adult survival in Ae. aegypti and Ae. albopictus. Using a novel simulation approach to harmonize disparate survival data, we conducted pooled survival analyses via stratified and mixed effects Cox regression to estimate temperature-dependent associations between humidity and mortality risk for these species across a broad range of temperatures and vapor pressure deficits. RESULTS: After screening 1517 articles, 17 studies (one in semi-field and 16 in laboratory settings) met inclusion criteria and collectively reported results for 192 survival experiments. We review and synthesize relevant findings from these studies. Our stratified model estimated a strong temperature-dependent association of humidity with mortality in both species, though associations were not significant for Ae. albopictus in the mixed effects model. Lowest mortality risks were estimated around 27.5 °C and 21.5 °C for Ae. aegypti and Ae. albopictus, respectively, and mortality increased non-linearly with decreasing humidity. Aedes aegypti had a survival advantage relative to Ae. albopictus in the stratified model under most conditions, but species differences were not significant in the mixed effects model. CONCLUSIONS: Humidity is associated with mortality risk in adult female Ae. aegypti in controlled settings. Data are limited at low humidities, temperature extremes, and for Ae. albopictus, and further studies should be conducted to reduce model uncertainty in these contexts. Desiccation is likely an important factor in Aedes population dynamics and viral transmission in arid regions. Models of Aedes-borne virus transmission may be improved by more comprehensively representing humidity effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13071-018-2808-6) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-25 /pmc/articles/PMC5918765/ /pubmed/29695282 http://dx.doi.org/10.1186/s13071-018-2808-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Schmidt, Chris A.
Comeau, Genevieve
Monaghan, Andrew J.
Williamson, Daniel J.
Ernst, Kacey C.
Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title_full Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title_fullStr Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title_full_unstemmed Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title_short Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): results of a systematic review and pooled survival analysis
title_sort effects of desiccation stress on adult female longevity in aedes aegypti and ae. albopictus (diptera: culicidae): results of a systematic review and pooled survival analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918765/
https://www.ncbi.nlm.nih.gov/pubmed/29695282
http://dx.doi.org/10.1186/s13071-018-2808-6
work_keys_str_mv AT schmidtchrisa effectsofdesiccationstressonadultfemalelongevityinaedesaegyptiandaealbopictusdipteraculicidaeresultsofasystematicreviewandpooledsurvivalanalysis
AT comeaugenevieve effectsofdesiccationstressonadultfemalelongevityinaedesaegyptiandaealbopictusdipteraculicidaeresultsofasystematicreviewandpooledsurvivalanalysis
AT monaghanandrewj effectsofdesiccationstressonadultfemalelongevityinaedesaegyptiandaealbopictusdipteraculicidaeresultsofasystematicreviewandpooledsurvivalanalysis
AT williamsondanielj effectsofdesiccationstressonadultfemalelongevityinaedesaegyptiandaealbopictusdipteraculicidaeresultsofasystematicreviewandpooledsurvivalanalysis
AT ernstkaceyc effectsofdesiccationstressonadultfemalelongevityinaedesaegyptiandaealbopictusdipteraculicidaeresultsofasystematicreviewandpooledsurvivalanalysis