Detection of Epstein‐Barr Virus DNA in a Japanese Case of Lymphoepithelioma‐like Thymic Carcinoma

Epstein‐Barr virus DNA was detected in a case of lymphoepithelioma‐like thymic carcinoma. A homogeneous terminal structure of the viral DNA was demonstrated in this case, indicating the presence of the viral genome in clonally expanded tumor cells. Since all of 26 other thymic epithelial tumors (eig...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuno, Yoshihiro, Mukai, Kiyoshi, Uhara, Hisashi, Akao, Ichiro, Furuya, Shuichiroh, Sato, Yuichi, Hirohashi, Setsuo, Shimosato, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918789/
https://www.ncbi.nlm.nih.gov/pubmed/1313408
http://dx.doi.org/10.1111/j.1349-7006.1992.tb00075.x
Descripción
Sumario:Epstein‐Barr virus DNA was detected in a case of lymphoepithelioma‐like thymic carcinoma. A homogeneous terminal structure of the viral DNA was demonstrated in this case, indicating the presence of the viral genome in clonally expanded tumor cells. Since all of 26 other thymic epithelial tumors (eight non‐invasive, 13 invasive thymomas and four non‐lymphoepithelioma‐like thymic carcinomas) in Japanese were negative by polymerase chain reaction, it is suggested that lymphoepithelioma‐like thymic carcinoma may represent a unique pathological entity distinct from Epstein‐Barr virus‐negative thymic epithelial tumors, which are in the majority in Japan.

Ejemplares similares