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Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice

Spontaneous lymphomas from a strain of hereditary cataract (CAC‐nct/+) mice were examined by light and electron microscopy and by immunohistochemical reaction for the mouse heavy and light immunoglobulin chains. Lymphomas occurred in 28 out of 45 male cataract mice and in 34 out of 52 females at 25...

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Detalles Bibliográficos
Autores principales: Hayashi, Shim‐mo, Nonoyama, Takashi, Miyajima, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918814/
https://www.ncbi.nlm.nih.gov/pubmed/1582891
http://dx.doi.org/10.1111/j.1349-7006.1992.tb00101.x
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author Hayashi, Shim‐mo
Nonoyama, Takashi
Miyajima, Hiroaki
author_facet Hayashi, Shim‐mo
Nonoyama, Takashi
Miyajima, Hiroaki
author_sort Hayashi, Shim‐mo
collection PubMed
description Spontaneous lymphomas from a strain of hereditary cataract (CAC‐nct/+) mice were examined by light and electron microscopy and by immunohistochemical reaction for the mouse heavy and light immunoglobulin chains. Lymphomas occurred in 28 out of 45 male cataract mice and in 34 out of 52 females at 25 to 65 weeks of age. All of the lymphoma‐bearing mice showed an enlargement of the spleen and mesenteric lymph nodes, and some mice also had hepatomegaly. Morphologically, all tumors were composed of a mixed population of small and large cells. Neoplastic cells had features of follicular center cell lymphomas, such as scant to moderate amounts of cytoplasm and cleaved and/or round nuclei with a large nuclear‐to‐cytoplasmic ratio. Large cells were often admixed with small cells, and had vesicular nuclei with prominent nucleoli juxtaposed to the nuclear membrane. Intracytoplasmic eosinophilic inclusions were observed in occasional cells, but Golgi apparatus was poorly developed and rough‐surfaced endoplasmic reticulum was scant, unlike those in plasma cells. C‐particles were seen in all lymphoma‐bearing mice by electron microscopy. Intracisternal A‐particles were detected in some mice. Immunohistochemically, neoplastic lymphoid cells were positive for the kappa light chain and the surface/cytoplasmic immunoglobulin M. These results indicate that lymphoid cell neoplasms found in hereditary cataract mice originate from follicular center B cells.
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spelling pubmed-59188142018-05-11 Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice Hayashi, Shim‐mo Nonoyama, Takashi Miyajima, Hiroaki Jpn J Cancer Res Article Spontaneous lymphomas from a strain of hereditary cataract (CAC‐nct/+) mice were examined by light and electron microscopy and by immunohistochemical reaction for the mouse heavy and light immunoglobulin chains. Lymphomas occurred in 28 out of 45 male cataract mice and in 34 out of 52 females at 25 to 65 weeks of age. All of the lymphoma‐bearing mice showed an enlargement of the spleen and mesenteric lymph nodes, and some mice also had hepatomegaly. Morphologically, all tumors were composed of a mixed population of small and large cells. Neoplastic cells had features of follicular center cell lymphomas, such as scant to moderate amounts of cytoplasm and cleaved and/or round nuclei with a large nuclear‐to‐cytoplasmic ratio. Large cells were often admixed with small cells, and had vesicular nuclei with prominent nucleoli juxtaposed to the nuclear membrane. Intracytoplasmic eosinophilic inclusions were observed in occasional cells, but Golgi apparatus was poorly developed and rough‐surfaced endoplasmic reticulum was scant, unlike those in plasma cells. C‐particles were seen in all lymphoma‐bearing mice by electron microscopy. Intracisternal A‐particles were detected in some mice. Immunohistochemically, neoplastic lymphoid cells were positive for the kappa light chain and the surface/cytoplasmic immunoglobulin M. These results indicate that lymphoid cell neoplasms found in hereditary cataract mice originate from follicular center B cells. Blackwell Publishing Ltd 1992-03 /pmc/articles/PMC5918814/ /pubmed/1582891 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00101.x Text en
spellingShingle Article
Hayashi, Shim‐mo
Nonoyama, Takashi
Miyajima, Hiroaki
Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title_full Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title_fullStr Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title_full_unstemmed Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title_short Spontaneous Follicular Center Cell Lymphomas of B Cell Origin in Cataract Mice
title_sort spontaneous follicular center cell lymphomas of b cell origin in cataract mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918814/
https://www.ncbi.nlm.nih.gov/pubmed/1582891
http://dx.doi.org/10.1111/j.1349-7006.1992.tb00101.x
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