Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the generation of a cell subpopulation with progenitor characte...

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Detalles Bibliográficos
Autores principales: Loomans, Cindy J.M., Williams Giuliani, Nerys, Balak, Jeetindra, Ringnalda, Femke, van Gurp, Léon, Huch, Meritxell, Boj, Sylvia F., Sato, Toshiro, Kester, Lennart, de Sousa Lopes, Susana M. Chuva, Roost, Matthias S., Bonner-Weir, Susan, Engelse, Marten A., Rabelink, Ton J., Heimberg, Harry, Vries, Robert G.J., van Oudenaarden, Alexander, Carlotti, Françoise, Clevers, Hans, de Koning, Eelco J.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918840/
https://www.ncbi.nlm.nih.gov/pubmed/29539434
http://dx.doi.org/10.1016/j.stemcr.2018.02.005

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