Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma

The long‐term T cell immunity to Epstein‐Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV‐infected B cells and outgrowth of EBV‐associated tumors. It can be manifested and quantified by the EBV‐induced focus regression assay. In the present study, we exami...

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Detalles Bibliográficos
Autores principales: Tamura, Shinji, Yamazaki, Atsushi, Kunimoto, Masaru, Takemura, Kiyoshi, Tabata, Toshihide, Hinuma, Yorio, Yoshie, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918858/
https://www.ncbi.nlm.nih.gov/pubmed/1319984
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01948.x
Descripción
Sumario:The long‐term T cell immunity to Epstein‐Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV‐infected B cells and outgrowth of EBV‐associated tumors. It can be manifested and quantified by the EBV‐induced focus regression assay. In the present study, we examined the strength of T cell immunity to EBV in patients with nasopharyngeal carcinoma (NPC) and other cancers originating from the head and neck region. In contrast to patients with other types of cancers, including EBV‐negative NPC, patients with EBV‐positive NPC were found to have a profound impairment in the long‐term T cell immunity to EBV.

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