Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma

The long‐term T cell immunity to Epstein‐Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV‐infected B cells and outgrowth of EBV‐associated tumors. It can be manifested and quantified by the EBV‐induced focus regression assay. In the present study, we exami...

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Autores principales: Tamura, Shinji, Yamazaki, Atsushi, Kunimoto, Masaru, Takemura, Kiyoshi, Tabata, Toshihide, Hinuma, Yorio, Yoshie, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918858/
https://www.ncbi.nlm.nih.gov/pubmed/1319984
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01948.x
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author Tamura, Shinji
Yamazaki, Atsushi
Kunimoto, Masaru
Takemura, Kiyoshi
Tabata, Toshihide
Hinuma, Yorio
Yoshie, Osamu
author_facet Tamura, Shinji
Yamazaki, Atsushi
Kunimoto, Masaru
Takemura, Kiyoshi
Tabata, Toshihide
Hinuma, Yorio
Yoshie, Osamu
author_sort Tamura, Shinji
collection PubMed
description The long‐term T cell immunity to Epstein‐Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV‐infected B cells and outgrowth of EBV‐associated tumors. It can be manifested and quantified by the EBV‐induced focus regression assay. In the present study, we examined the strength of T cell immunity to EBV in patients with nasopharyngeal carcinoma (NPC) and other cancers originating from the head and neck region. In contrast to patients with other types of cancers, including EBV‐negative NPC, patients with EBV‐positive NPC were found to have a profound impairment in the long‐term T cell immunity to EBV.
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spelling pubmed-59188582018-05-11 Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma Tamura, Shinji Yamazaki, Atsushi Kunimoto, Masaru Takemura, Kiyoshi Tabata, Toshihide Hinuma, Yorio Yoshie, Osamu Jpn J Cancer Res Article The long‐term T cell immunity to Epstein‐Barr virus (EBV) is considered to play an important role in suppressing proliferation of EBV‐infected B cells and outgrowth of EBV‐associated tumors. It can be manifested and quantified by the EBV‐induced focus regression assay. In the present study, we examined the strength of T cell immunity to EBV in patients with nasopharyngeal carcinoma (NPC) and other cancers originating from the head and neck region. In contrast to patients with other types of cancers, including EBV‐negative NPC, patients with EBV‐positive NPC were found to have a profound impairment in the long‐term T cell immunity to EBV. Blackwell Publishing Ltd 1992-05 /pmc/articles/PMC5918858/ /pubmed/1319984 http://dx.doi.org/10.1111/j.1349-7006.1992.tb01948.x Text en
spellingShingle Article
Tamura, Shinji
Yamazaki, Atsushi
Kunimoto, Masaru
Takemura, Kiyoshi
Tabata, Toshihide
Hinuma, Yorio
Yoshie, Osamu
Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title_full Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title_fullStr Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title_full_unstemmed Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title_short Impaired Long‐term T Cell Immunity to Epstein‐Barr Virus in Patients with Nasopharyngeal Carcinoma
title_sort impaired long‐term t cell immunity to epstein‐barr virus in patients with nasopharyngeal carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918858/
https://www.ncbi.nlm.nih.gov/pubmed/1319984
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01948.x
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