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In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody
With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c‐erbB‐2 gene product, and the other arm recognized CD3ɛ, a T‐cell specific surface antigen. Application of this BFA wit...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1992
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918874/ https://www.ncbi.nlm.nih.gov/pubmed/1353752 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00126.x |
| _version_ | 1783317510889668608 |
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| author | Sugiyama, Yoshihiro Aihara, Miki Shibamori, Masafumi Deguchi, Kyohei Imagawa, Kenichi Kikuchi, Mikio Momota, Hiroshi Azuma, Takachika Okada, Hidechika Alper, Özge Hitomi, Jiro Yamaguchi, Ken |
| author_facet | Sugiyama, Yoshihiro Aihara, Miki Shibamori, Masafumi Deguchi, Kyohei Imagawa, Kenichi Kikuchi, Mikio Momota, Hiroshi Azuma, Takachika Okada, Hidechika Alper, Özge Hitomi, Jiro Yamaguchi, Ken |
| author_sort | Sugiyama, Yoshihiro |
| collection | PubMed |
| description | With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c‐erbB‐2 gene product, and the other arm recognized CD3ɛ, a T‐cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti‐tumor activity in vitro on a breast tumor cell line, ZR‐75–1, which expressed abundant c‐erbB‐2 gene product on its cell surface. These results indicate that BFA recognizing an oncogene product on cell surface is a potential new agent for cancer immunotherapy. |
| format | Online Article Text |
| id | pubmed-5918874 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1992 |
| publisher | Blackwell Publishing Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59188742018-05-11 In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody Sugiyama, Yoshihiro Aihara, Miki Shibamori, Masafumi Deguchi, Kyohei Imagawa, Kenichi Kikuchi, Mikio Momota, Hiroshi Azuma, Takachika Okada, Hidechika Alper, Özge Hitomi, Jiro Yamaguchi, Ken Jpn J Cancer Res Rapid Communication With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c‐erbB‐2 gene product, and the other arm recognized CD3ɛ, a T‐cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti‐tumor activity in vitro on a breast tumor cell line, ZR‐75–1, which expressed abundant c‐erbB‐2 gene product on its cell surface. These results indicate that BFA recognizing an oncogene product on cell surface is a potential new agent for cancer immunotherapy. Blackwell Publishing Ltd 1992-06 /pmc/articles/PMC5918874/ /pubmed/1353752 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00126.x Text en |
| spellingShingle | Rapid Communication Sugiyama, Yoshihiro Aihara, Miki Shibamori, Masafumi Deguchi, Kyohei Imagawa, Kenichi Kikuchi, Mikio Momota, Hiroshi Azuma, Takachika Okada, Hidechika Alper, Özge Hitomi, Jiro Yamaguchi, Ken In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title | In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title_full | In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title_fullStr | In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title_full_unstemmed | In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title_short | In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal Antibody |
| title_sort | in vitro anti‐tumor activity of anti‐c‐erbb‐2 × anti‐cd3ɛ bifunctional monoclonal antibody |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918874/ https://www.ncbi.nlm.nih.gov/pubmed/1353752 http://dx.doi.org/10.1111/j.1349-7006.1992.tb00126.x |
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