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Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany
BACKGROUND: People who inject drugs (PWID) are disproportionately affected by both HIV and hepatitis C infection (HCV). Awareness of infection status is essential to ensure linkage to appropriate healthcare for those infected, who need treatment and regular follow-up, as well as for uninfected indiv...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918911/ https://www.ncbi.nlm.nih.gov/pubmed/30288312 http://dx.doi.org/10.1186/s41124-016-0016-6 |
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author | Nielsen, Stine Gassowski, Martyna Wenz, Benjamin Bannert, Norbert Bock, Claus-Thomas Kücherer, Claudia Ross, R. Stefan Bremer, Viviane Marcus, Ulrich Zimmermann, Ruth |
author_facet | Nielsen, Stine Gassowski, Martyna Wenz, Benjamin Bannert, Norbert Bock, Claus-Thomas Kücherer, Claudia Ross, R. Stefan Bremer, Viviane Marcus, Ulrich Zimmermann, Ruth |
author_sort | Nielsen, Stine |
collection | PubMed |
description | BACKGROUND: People who inject drugs (PWID) are disproportionately affected by both HIV and hepatitis C infection (HCV). Awareness of infection status is essential to ensure linkage to appropriate healthcare for those infected, who need treatment and regular follow-up, as well as for uninfected individuals, who need access to targeted testing and counselling services. In this paper we compare self-reported HIV and HCV status with serological markers of infection among PWID recruited through respondent driven sampling. METHODS: From 2011 through 2014, biological and behavioural data was collected from 2,077 PWID in Germany. Dried blood spots from capillary blood samples were collected and screened for HCV antibodies, HCV RNA and HIV-1/-2 antibodies. HIV reactive samples were confirmed by Western blot. RESULTS: Laboratory testing revealed that 5 % were infected with HIV and 81 % were aware of being infected. Chronic HCV infection was detected in 41 % of the participants, 2 % had an acute HCV infection, 22 % had a cleared infection, and 34 % were unexposed to HCV. The concordance between self-reported and measured HCV status was lower than for HIV, with 73 % of those with chronic HCV infection being aware of their infection. CONCLUSIONS: We found a relatively high awareness of HIV and HCV infection status among PWID. Nevertheless, access to appropriate testing, counselling and care services targeted to the needs of PWID should be further improved, particularly concerning HCV. TRIAL REGISTRATION: Ethical approval was received from the ethics committee at the medical university of Charité, Berlin, Germany in May 2011 and with an amendment approved retrospectively on 19/11/2012 (No EA4/036/11). The German Federal Commissioner for Data Protection and Freedom of Information approved the study protocol retrospectively on 29/11/2012 (III-401/008#0035). |
format | Online Article Text |
id | pubmed-5918911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59189112018-10-04 Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany Nielsen, Stine Gassowski, Martyna Wenz, Benjamin Bannert, Norbert Bock, Claus-Thomas Kücherer, Claudia Ross, R. Stefan Bremer, Viviane Marcus, Ulrich Zimmermann, Ruth Hepatol Med Policy Research BACKGROUND: People who inject drugs (PWID) are disproportionately affected by both HIV and hepatitis C infection (HCV). Awareness of infection status is essential to ensure linkage to appropriate healthcare for those infected, who need treatment and regular follow-up, as well as for uninfected individuals, who need access to targeted testing and counselling services. In this paper we compare self-reported HIV and HCV status with serological markers of infection among PWID recruited through respondent driven sampling. METHODS: From 2011 through 2014, biological and behavioural data was collected from 2,077 PWID in Germany. Dried blood spots from capillary blood samples were collected and screened for HCV antibodies, HCV RNA and HIV-1/-2 antibodies. HIV reactive samples were confirmed by Western blot. RESULTS: Laboratory testing revealed that 5 % were infected with HIV and 81 % were aware of being infected. Chronic HCV infection was detected in 41 % of the participants, 2 % had an acute HCV infection, 22 % had a cleared infection, and 34 % were unexposed to HCV. The concordance between self-reported and measured HCV status was lower than for HIV, with 73 % of those with chronic HCV infection being aware of their infection. CONCLUSIONS: We found a relatively high awareness of HIV and HCV infection status among PWID. Nevertheless, access to appropriate testing, counselling and care services targeted to the needs of PWID should be further improved, particularly concerning HCV. TRIAL REGISTRATION: Ethical approval was received from the ethics committee at the medical university of Charité, Berlin, Germany in May 2011 and with an amendment approved retrospectively on 19/11/2012 (No EA4/036/11). The German Federal Commissioner for Data Protection and Freedom of Information approved the study protocol retrospectively on 29/11/2012 (III-401/008#0035). BioMed Central 2016-09-01 /pmc/articles/PMC5918911/ /pubmed/30288312 http://dx.doi.org/10.1186/s41124-016-0016-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Nielsen, Stine Gassowski, Martyna Wenz, Benjamin Bannert, Norbert Bock, Claus-Thomas Kücherer, Claudia Ross, R. Stefan Bremer, Viviane Marcus, Ulrich Zimmermann, Ruth Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title | Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title_full | Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title_fullStr | Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title_full_unstemmed | Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title_short | Concordance between self-reported and measured HIV and hepatitis C virus infection status among people who inject drugs in Germany |
title_sort | concordance between self-reported and measured hiv and hepatitis c virus infection status among people who inject drugs in germany |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918911/ https://www.ncbi.nlm.nih.gov/pubmed/30288312 http://dx.doi.org/10.1186/s41124-016-0016-6 |
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