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Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model

The efficacy of a wide‐spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N‐bis(2‐hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N...

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Autores principales: Uwagawa, Satoshi, Tsuda, Hiroyuki, Ozaki, Keisuke, Takahashi, Satoru, Yamaguchi, Shuji, Mutai, Mamoru, Aoki, Toyohiko, Ito, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918946/
https://www.ncbi.nlm.nih.gov/pubmed/1399818
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01985.x
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author Uwagawa, Satoshi
Tsuda, Hiroyuki
Ozaki, Keisuke
Takahashi, Satoru
Yamaguchi, Shuji
Mutai, Mamoru
Aoki, Toyohiko
Ito, Nobuyuki
author_facet Uwagawa, Satoshi
Tsuda, Hiroyuki
Ozaki, Keisuke
Takahashi, Satoru
Yamaguchi, Shuji
Mutai, Mamoru
Aoki, Toyohiko
Ito, Nobuyuki
author_sort Uwagawa, Satoshi
collection PubMed
description The efficacy of a wide‐spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N‐bis(2‐hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N‐ethyl‐N‐hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2′‐dimethyl‐4‐aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide‐spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non‐hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2‐acetylaminofluorene, ethionine, and 3′‐methyl‐4‐dimethylaminoazobenzene; in the liver and thyroid with 4,4′‐diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12‐dimethylbenz[a]anthracene and in the liver and lung with 3‐methylcholanthrene. Inhibitory effects on development of glutathione S‐transferase placental form‐positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium‐term bioassay system for assessment of environmental cancer modifiers.
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spelling pubmed-59189462018-05-11 Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model Uwagawa, Satoshi Tsuda, Hiroyuki Ozaki, Keisuke Takahashi, Satoru Yamaguchi, Shuji Mutai, Mamoru Aoki, Toyohiko Ito, Nobuyuki Jpn J Cancer Res Article The efficacy of a wide‐spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N‐bis(2‐hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N‐ethyl‐N‐hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2′‐dimethyl‐4‐aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide‐spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non‐hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2‐acetylaminofluorene, ethionine, and 3′‐methyl‐4‐dimethylaminoazobenzene; in the liver and thyroid with 4,4′‐diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12‐dimethylbenz[a]anthracene and in the liver and lung with 3‐methylcholanthrene. Inhibitory effects on development of glutathione S‐transferase placental form‐positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium‐term bioassay system for assessment of environmental cancer modifiers. Blackwell Publishing Ltd 1992-08 /pmc/articles/PMC5918946/ /pubmed/1399818 http://dx.doi.org/10.1111/j.1349-7006.1992.tb01985.x Text en
spellingShingle Article
Uwagawa, Satoshi
Tsuda, Hiroyuki
Ozaki, Keisuke
Takahashi, Satoru
Yamaguchi, Shuji
Mutai, Mamoru
Aoki, Toyohiko
Ito, Nobuyuki
Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title_full Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title_fullStr Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title_full_unstemmed Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title_short Modifying Effects of Various Chemicals on Tumor Development in a Rat Wide‐spectrum Organ Carcinogenesis Model
title_sort modifying effects of various chemicals on tumor development in a rat wide‐spectrum organ carcinogenesis model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918946/
https://www.ncbi.nlm.nih.gov/pubmed/1399818
http://dx.doi.org/10.1111/j.1349-7006.1992.tb01985.x
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