Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines

Eight cell lines were established from patients with adult T‐cell leukemia, and from normal adults, by cocultivation with human T‐cell leukemia virus type I(HTLV‐I)‐producer cell lines in the presence of interleukin‐2. All of these cell lines harbored HTLV‐I and showed T‐cell markers CD2, CD3 and CD...

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Autores principales: Koizumi, Shigeki, Sugiura, Makoto, Zhang, Xian‐Kui, Yamashiro, Katsushige, Iwanaga, Michiyo, Imai, Shosuke, Osato, Toyoro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1992
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918981/
https://www.ncbi.nlm.nih.gov/pubmed/1429201
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02002.x
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author Koizumi, Shigeki
Sugiura, Makoto
Zhang, Xian‐Kui
Yamashiro, Katsushige
Iwanaga, Michiyo
Imai, Shosuke
Osato, Toyoro
author_facet Koizumi, Shigeki
Sugiura, Makoto
Zhang, Xian‐Kui
Yamashiro, Katsushige
Iwanaga, Michiyo
Imai, Shosuke
Osato, Toyoro
author_sort Koizumi, Shigeki
collection PubMed
description Eight cell lines were established from patients with adult T‐cell leukemia, and from normal adults, by cocultivation with human T‐cell leukemia virus type I(HTLV‐I)‐producer cell lines in the presence of interleukin‐2. All of these cell lines harbored HTLV‐I and showed T‐cell markers CD2, CD3 and CD4, hut not B‐cell markers. Unexpectedly, all eight cell lines expressed a myeloid marker CD13 and three of the eight lines also expressed another myeloid marker CD33. Dual staining showed the simultaneous expression of CD3 and CD13 on the same cells. Thus, evidence was obtained for the expression of myeloid antigens on HTLV‐I‐harboring T cells.
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spelling pubmed-59189812018-05-11 Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines Koizumi, Shigeki Sugiura, Makoto Zhang, Xian‐Kui Yamashiro, Katsushige Iwanaga, Michiyo Imai, Shosuke Osato, Toyoro Jpn J Cancer Res Rapid Communication Eight cell lines were established from patients with adult T‐cell leukemia, and from normal adults, by cocultivation with human T‐cell leukemia virus type I(HTLV‐I)‐producer cell lines in the presence of interleukin‐2. All of these cell lines harbored HTLV‐I and showed T‐cell markers CD2, CD3 and CD4, hut not B‐cell markers. Unexpectedly, all eight cell lines expressed a myeloid marker CD13 and three of the eight lines also expressed another myeloid marker CD33. Dual staining showed the simultaneous expression of CD3 and CD13 on the same cells. Thus, evidence was obtained for the expression of myeloid antigens on HTLV‐I‐harboring T cells. Blackwell Publishing Ltd 1992-09 /pmc/articles/PMC5918981/ /pubmed/1429201 http://dx.doi.org/10.1111/j.1349-7006.1992.tb02002.x Text en
spellingShingle Rapid Communication
Koizumi, Shigeki
Sugiura, Makoto
Zhang, Xian‐Kui
Yamashiro, Katsushige
Iwanaga, Michiyo
Imai, Shosuke
Osato, Toyoro
Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title_full Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title_fullStr Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title_full_unstemmed Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title_short Simultaneous Expression of T‐Cell and Myeloid Cell Phenotypes in Eight Newly Established HTLV‐I‐positive T‐Cell Lines
title_sort simultaneous expression of t‐cell and myeloid cell phenotypes in eight newly established htlv‐i‐positive t‐cell lines
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918981/
https://www.ncbi.nlm.nih.gov/pubmed/1429201
http://dx.doi.org/10.1111/j.1349-7006.1992.tb02002.x
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