Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets

The effects of a high‐fat diet and esculetin were investigated on 7,12‐dimethylbenz[α]anthracene (DMBA)‐induced mammary carcinogenesis in female Sprague‐Dawley rats. Rats were given a 5‐mg dose of DMBA. Seven days later, they were fed either a high‐fat (20% soybean oil) or low‐fat (0.5% soybean oil)...

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Autores principales: Noguchi, Masakuni, Kitagawa, Hirohisa, Miyazaki, Itsuo, Mizukami, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919062/
https://www.ncbi.nlm.nih.gov/pubmed/8226274
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02793.x
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author Noguchi, Masakuni
Kitagawa, Hirohisa
Miyazaki, Itsuo
Mizukami, Yuji
author_facet Noguchi, Masakuni
Kitagawa, Hirohisa
Miyazaki, Itsuo
Mizukami, Yuji
author_sort Noguchi, Masakuni
collection PubMed
description The effects of a high‐fat diet and esculetin were investigated on 7,12‐dimethylbenz[α]anthracene (DMBA)‐induced mammary carcinogenesis in female Sprague‐Dawley rats. Rats were given a 5‐mg dose of DMBA. Seven days later, they were fed either a high‐fat (20% soybean oil) or low‐fat (0.5% soybean oil) diet. A half of the rats received diets containing 0.03% esculetin. Esculetin significantly inhibited tumor incidence, growth and cell kinetics of the tumor in the rats fed the high‐fat and the low‐fat diets. Our findings indicate that DMBA‐induced mammary tumorigenesis is affected by lipoxygenase products.
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spelling pubmed-59190622018-05-11 Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets Noguchi, Masakuni Kitagawa, Hirohisa Miyazaki, Itsuo Mizukami, Yuji Jpn J Cancer Res Rapid Communication The effects of a high‐fat diet and esculetin were investigated on 7,12‐dimethylbenz[α]anthracene (DMBA)‐induced mammary carcinogenesis in female Sprague‐Dawley rats. Rats were given a 5‐mg dose of DMBA. Seven days later, they were fed either a high‐fat (20% soybean oil) or low‐fat (0.5% soybean oil) diet. A half of the rats received diets containing 0.03% esculetin. Esculetin significantly inhibited tumor incidence, growth and cell kinetics of the tumor in the rats fed the high‐fat and the low‐fat diets. Our findings indicate that DMBA‐induced mammary tumorigenesis is affected by lipoxygenase products. Blackwell Publishing Ltd 1993-10 /pmc/articles/PMC5919062/ /pubmed/8226274 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02793.x Text en
spellingShingle Rapid Communication
Noguchi, Masakuni
Kitagawa, Hirohisa
Miyazaki, Itsuo
Mizukami, Yuji
Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title_full Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title_fullStr Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title_full_unstemmed Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title_short Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets
title_sort influence of esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12‐dimethylbenz[α]anthracene in rats on high‐ and low‐fat diets
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919062/
https://www.ncbi.nlm.nih.gov/pubmed/8226274
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02793.x
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