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Production, Binding and Cytotoxicity of Human/Mouse Chimeric Monoclonal Antibody‐Neocarzinostatin Conjugate

A human/mouse chimeric Fab monoclonal antibody A7 (chFabA7) was covalently coupled to neocarzinostatin (NCS) by the SPDP method at various chFabA7:NCS substitution ratios. The antigen‐binding activity of the conjugate, examined by ELISA using fixed antigen‐positive colon cancer cells, was identical...

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Detalles Bibliográficos
Autores principales:	Yamaguchi, Toshiharu, Tsurumi, Hiroshi, Kitamura, Kazuya, Otsuji, Eigo, Miyagaki, Takuya, Kotani, Tatsuya, Takahashi, Toshio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1993
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919093/ https://www.ncbi.nlm.nih.gov/pubmed/8276723 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02820.x

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