Chromosomal Assignment of the Gene for Protein Tyrosine Phosphatase HPTPδ

Protein tyrosine phosphatase (PTP) negatively regulates the effect of protein tyrosine kinases and is implicated in the regulation of a variety of biological phenomena such as cell activation, differentiation and neoplastic transformation. To gain insight into the role of PTPs, we cloned the human r...

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Detalles Bibliográficos
Autores principales: Hasegawa, Kiminori, Ariyama, Takeshi, Inazawa, Johji, Mizuno, Kazuya, Ogimoto, Mami, Katagiri, Tatsuo, Yakura, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919108/
https://www.ncbi.nlm.nih.gov/pubmed/8294211
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02825.x
Descripción
Sumario:Protein tyrosine phosphatase (PTP) negatively regulates the effect of protein tyrosine kinases and is implicated in the regulation of a variety of biological phenomena such as cell activation, differentiation and neoplastic transformation. To gain insight into the role of PTPs, we cloned the human receptor‐type FTP gene and assigned the chromosome harboring the gene for HPTPδ by using DNAs from human‐mouse hybrid cell lines and by fluorescence in situ hybridization. The results clearly demonstrated that HPTPδ gene maps to human chromosome 9p24.

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