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Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water
Establishment of an animal model of stomach carcinogenesis in mice was attempted using N‐methyl‐N‐nitrosourea (MNU) in the drinking water. One hundred and forty‐eight male 6‐week‐old C3H mice were given MNU in their drinking water at a concentration of 120 ppm (group 1), 60 ppm (group 2), 30 ppm (gr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1993
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919110/ https://www.ncbi.nlm.nih.gov/pubmed/8294216 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02831.x |
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author | Tatematsu, Masae Yamamoto, Masami Iwata, Hitoshi Fukami, Hiroko Yuasa, Hirofumi Tezuka, Noriaki Masui, Tsuneo Nakanishi, Hayao |
author_facet | Tatematsu, Masae Yamamoto, Masami Iwata, Hitoshi Fukami, Hiroko Yuasa, Hirofumi Tezuka, Noriaki Masui, Tsuneo Nakanishi, Hayao |
author_sort | Tatematsu, Masae |
collection | PubMed |
description | Establishment of an animal model of stomach carcinogenesis in mice was attempted using N‐methyl‐N‐nitrosourea (MNU) in the drinking water. One hundred and forty‐eight male 6‐week‐old C3H mice were given MNU in their drinking water at a concentration of 120 ppm (group 1), 60 ppm (group 2), 30 ppm (group 3) or 0 ppm (group 4) for 30 weeks. At the end of this time, dose‐related induction of adenomatous hyperplasias was found. From weeks 31 to 54 adenocarcinomas developed in a dose‐dependent manner in groups 1, 2 and 3. In total, 6 well differentiated and 5 poorly differentiated adenocarcinomas as well as 6 signet ring cell carcinomas arose in 15 stomach cancer‐bearing animals in group 1, 4 well differentiated and 2 poorly differentiated adenocarcinomas with one signet ring cell carcinoma in 5 mice of group 2 and one well differentiated adenocarcinoma in group 3. In the forestomach, only one squamous cell carcinoma was found at week 54 in group 1 along with a single well differentiated adenocarcinoma in the duodenum. Thus, MNU in the drinking water selectively induced neoplastic lesions in the glandular stomach epithelium of mice. |
format | Online Article Text |
id | pubmed-5919110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59191102018-05-11 Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water Tatematsu, Masae Yamamoto, Masami Iwata, Hitoshi Fukami, Hiroko Yuasa, Hirofumi Tezuka, Noriaki Masui, Tsuneo Nakanishi, Hayao Jpn J Cancer Res Article Establishment of an animal model of stomach carcinogenesis in mice was attempted using N‐methyl‐N‐nitrosourea (MNU) in the drinking water. One hundred and forty‐eight male 6‐week‐old C3H mice were given MNU in their drinking water at a concentration of 120 ppm (group 1), 60 ppm (group 2), 30 ppm (group 3) or 0 ppm (group 4) for 30 weeks. At the end of this time, dose‐related induction of adenomatous hyperplasias was found. From weeks 31 to 54 adenocarcinomas developed in a dose‐dependent manner in groups 1, 2 and 3. In total, 6 well differentiated and 5 poorly differentiated adenocarcinomas as well as 6 signet ring cell carcinomas arose in 15 stomach cancer‐bearing animals in group 1, 4 well differentiated and 2 poorly differentiated adenocarcinomas with one signet ring cell carcinoma in 5 mice of group 2 and one well differentiated adenocarcinoma in group 3. In the forestomach, only one squamous cell carcinoma was found at week 54 in group 1 along with a single well differentiated adenocarcinoma in the duodenum. Thus, MNU in the drinking water selectively induced neoplastic lesions in the glandular stomach epithelium of mice. Blackwell Publishing Ltd 1993-12 /pmc/articles/PMC5919110/ /pubmed/8294216 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02831.x Text en |
spellingShingle | Article Tatematsu, Masae Yamamoto, Masami Iwata, Hitoshi Fukami, Hiroko Yuasa, Hirofumi Tezuka, Noriaki Masui, Tsuneo Nakanishi, Hayao Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title | Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title_full | Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title_fullStr | Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title_full_unstemmed | Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title_short | Induction of Glandular Stomach Cancers in C3H Mice Treated with N‐Methyl‐N‐nitrosourea in the Drinking Water |
title_sort | induction of glandular stomach cancers in c3h mice treated with n‐methyl‐n‐nitrosourea in the drinking water |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919110/ https://www.ncbi.nlm.nih.gov/pubmed/8294216 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02831.x |
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