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H‐2(Z) Homozygous New Zealand Mice as a Model for B‐Cell Chronic Lymphocytic Leukemia: Elevated bcl‐2 Expression in CD5 B Cells at Premalignant and Malignant Stages

In New Zealand mice, the major histocompatibility complex (MHC) controls the development of both autoimmune disease and B cell chronic lymphocytic leukemia (B‐CLL). While H‐2(d)/H‐2(z) heterozygosity acts as one major predisposing genetic element for autoimmune disease, H‐2(z)/H‐2(z) homozygosity ac...

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Detalles Bibliográficos
Autores principales:	Okamoto, Hiroshi, Nishimura, Hiroyuki, Shinozaki, Ayako, Zhang, Danqing, Hirose, Sachiko, Shirai, Toshikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1993
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919115/ https://www.ncbi.nlm.nih.gov/pubmed/7507474 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02834.x

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