Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers

Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were...

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Detalles Bibliográficos
Autores principales: Iwahara, Yoshihito, Sawada, Takashi, Taguchi, Hirokuni, Hoshino, Hiroo, Umemoto, Masakazu, Take, Hiromichi, Foung, Steven, Miyoshi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919125/
https://www.ncbi.nlm.nih.gov/pubmed/8385083
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02842.x
Descripción
Sumario:Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV‐I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3–6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV‐I remains to be studied.

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