Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers

Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were...

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Autores principales: Iwahara, Yoshihito, Sawada, Takashi, Taguchi, Hirokuni, Hoshino, Hiroo, Umemoto, Masakazu, Take, Hiromichi, Foung, Steven, Miyoshi, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919125/
https://www.ncbi.nlm.nih.gov/pubmed/8385083
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02842.x
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author Iwahara, Yoshihito
Sawada, Takashi
Taguchi, Hirokuni
Hoshino, Hiroo
Umemoto, Masakazu
Take, Hiromichi
Foung, Steven
Miyoshi, Isao
author_facet Iwahara, Yoshihito
Sawada, Takashi
Taguchi, Hirokuni
Hoshino, Hiroo
Umemoto, Masakazu
Take, Hiromichi
Foung, Steven
Miyoshi, Isao
author_sort Iwahara, Yoshihito
collection PubMed
description Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV‐I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3–6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV‐I remains to be studied.
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spelling pubmed-59191252018-05-11 Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers Iwahara, Yoshihito Sawada, Takashi Taguchi, Hirokuni Hoshino, Hiroo Umemoto, Masakazu Take, Hiromichi Foung, Steven Miyoshi, Isao Jpn J Cancer Res Rapid Communication Breast feeding is the major route of mother‐to‐child transmission of human T‐cell leukemia virus type I (HTLV‐I). Our experiments with rabbits have shown that passive immunization is capable of blocking ceil‐to‐cell infection of HTLV‐I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV‐I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3–6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV‐I remains to be studied. Blackwell Publishing Ltd 1993-02 /pmc/articles/PMC5919125/ /pubmed/8385083 http://dx.doi.org/10.1111/j.1349-7006.1993.tb02842.x Text en
spellingShingle Rapid Communication
Iwahara, Yoshihito
Sawada, Takashi
Taguchi, Hirokuni
Hoshino, Hiroo
Umemoto, Masakazu
Take, Hiromichi
Foung, Steven
Miyoshi, Isao
Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title_full Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title_fullStr Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title_full_unstemmed Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title_short Neutralizing Antibody to Vesicular Stomatitis Virus (HTLV‐I) Pseudotype in Infants Born to Seropositive Mothers
title_sort neutralizing antibody to vesicular stomatitis virus (htlv‐i) pseudotype in infants born to seropositive mothers
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919125/
https://www.ncbi.nlm.nih.gov/pubmed/8385083
http://dx.doi.org/10.1111/j.1349-7006.1993.tb02842.x
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