Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor

Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking e...

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Detalles Bibliográficos
Autores principales: Sato, Yasufumi, Waki, Michinori, Ohno, Motonori, Kuwano, Michihiko, Sakata, Toshiie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1993
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919175/
https://www.ncbi.nlm.nih.gov/pubmed/8320164
http://dx.doi.org/10.1111/j.1349-7006.1993.tb00163.x
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author Sato, Yasufumi
Waki, Michinori
Ohno, Motonori
Kuwano, Michihiko
Sakata, Toshiie
author_facet Sato, Yasufumi
Waki, Michinori
Ohno, Motonori
Kuwano, Michihiko
Sakata, Toshiie
author_sort Sato, Yasufumi
collection PubMed
description Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).
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spelling pubmed-59191752018-05-11 Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor Sato, Yasufumi Waki, Michinori Ohno, Motonori Kuwano, Michihiko Sakata, Toshiie Jpn J Cancer Res Rapid Communication Platelet factor 4 (PF‐4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl‐terminal fragments, which represent the heparin‐binding region of the PF‐4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF). Blackwell Publishing Ltd 1993-05 /pmc/articles/PMC5919175/ /pubmed/8320164 http://dx.doi.org/10.1111/j.1349-7006.1993.tb00163.x Text en
spellingShingle Rapid Communication
Sato, Yasufumi
Waki, Michinori
Ohno, Motonori
Kuwano, Michihiko
Sakata, Toshiie
Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title_full Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title_fullStr Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title_full_unstemmed Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title_short Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor
title_sort carboxyl‐terminal heparin‐binding fragments of platelet factor 4 retain the blocking effect on the receptor binding of basic fibroblast growth factor
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919175/
https://www.ncbi.nlm.nih.gov/pubmed/8320164
http://dx.doi.org/10.1111/j.1349-7006.1993.tb00163.x
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