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DNA Damage and Cell Killing by Camptothecin and Its Derivative in Human Leukemia HL‐60 Cells

Camptothecin (CPT) has heen recognized as a topoisomerase I (Topo I) inhibitor. However, the mechanism of cytotoxicity of this agent remains unknown. In the present study, we analyzed the kinetics of Topo I‐mediated DNA single‐strand breaks and internucleosomal DNA cleavage produced by CPT and its d...

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Detalles Bibliográficos
Autores principales:	Yoshida, Akira, Ueda, Takanori, Wano, Yuji, Nakamura, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1993
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919177/ https://www.ncbi.nlm.nih.gov/pubmed/8391526 http://dx.doi.org/10.1111/j.1349-7006.1993.tb00177.x

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